Publications by authors named "N J Warren"
Previous studies have suggested that choroid plexus (ChP) enlargement occurs in individuals with schizophrenia-spectrum disorders (SSD) and is associated with peripheral inflammation. However, it is unclear whether such an enlargement delineates a biologically defined subgroup of SSD. Moreover, it remains elusive how ChP is linked to brain regions associated with peripheral inflammation in SSD.
View Article and Find Full Text PDFIntroduction And Objectives: Clozapine is the antipsychotic medication with the greatest efficacy in treatment-resistant schizophrenia (TRS). Unfortunately, clozapine is ceased in approximately 0.2% to 8.
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- * Using a large Queensland cohort, the research found that 10.1% of participants had been reported for child maltreatment, with 3.3% admitted and 4.8% presenting at emergency departments for CMDs.
- * The results indicate that all forms of substantiated child maltreatment significantly correlated with increased risk for CMDs, particularly anxiety and depression, suggesting a need for better screening for maltreatment in hospital settings.
Background: There is a high incidence of serious mental illness (SMI) and antipsychotic use in the respiratory high dependence unit (HDU) compared with the general population. However, there is a paucity of data in the extant literature evaluating the relationships between respiratory failure and antipsychotics.
Aims: To investigate the relationship between antipsychotics and respiratory failure in people admitted to a respiratory HDU, and to gain a better understanding of the potential impact of antipsychotic medications on respiratory outcomes.
Article Synopsis
- The text discusses the challenges of oral antibiotic treatment for acute bacterial skin infections, highlighting that existing guidelines do not adequately address common skin pathogens.
- A post hoc analysis of two phase 3 clinical trials (OASIS-1 and OASIS-2) compares the safety and efficacy of starting treatment with intravenous (IV) therapy versus oral (PO) therapy using omadacycline or linezolid.
- Results show that both treatment methods are similarly effective, with comparable rates of early clinical response and adverse events, suggesting oral therapy is a viable option for treating these infections.