Publications by authors named "N J Vigna"
Article Synopsis
- Upadacitinib shows faster and more effective results in reducing atopic dermatitis severity compared to dupilumab over 24 weeks, based on the Eczema Area and Severity Index (EASI).
- In a study, patients treated with upadacitinib achieved greater skin clearance rates of ≥75%, ≥90%, and 100% in all analyzed body regions earlier than those on dupilumab.
- Patient feedback indicated that those on upadacitinib reported significantly better outcomes for symptoms in the head and neck area as soon as week 1.
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritic eczematous lesions. The effect of treatment withdrawal after response to upadacitinib oral treatment is not fully characterized.
Objectives: Assess the effect of upadacitinib withdrawal on skin clearance and itch improvement in adult patients with moderate-to-severe AD and evaluate the kinetics of recovery on rescue treatment.
Background: Patients with moderate-to-severe atopic dermatitis (AD) experience skin lesions and intense itch that substantially affect quality of life. Patients have choices among systemic AD treatments that offer varied benefit-risk profiles.
Objective: Measure patients' willingness to trade off the risks and benefits of systemic treatments among individuals with a physician-confirmed diagnosis of moderate-to-severe AD.
Article Synopsis
- - Upadacitinib treatment for moderate-to-severe atopic dermatitis frequently leads to acne as an adverse event, with rates varying based on dosage and demographic factors.
- - In a study of 2,583 participants, acne occurred in 9.8% to 15.2% of patients receiving upadacitinib, mostly presenting as mild to moderate, and primarily managed without medical intervention.
- - The study highlights the need for further research due to its brief duration and small sample size, but overall, acne did not significantly affect patients' quality of life.
We assessed pollicizations performed by one surgeon; compared function of the pollicized digit in patients with and without forearm/wrist anomalies; and determined if hand function changed with age. A total of 42 hands were assessed an average of 5.7 years post-operatively, 21 with a forearm/wrist anomaly (Group 1) and 21 without (Group 2).
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