Publications by authors named "N J Verkaik"
Article Synopsis
- A significant rise in multidrug-resistant microorganisms (MDRO) was noted following the transfer of Ukrainian patients to hospitals, with various resistant strains identified, including carbapenem-resistant bacteria.
- Testing for antimicrobial susceptibility showed low efficacy rates for several last-resort antibiotics, highlighting severe resistance issues among these pathogens.
- Factors influencing cefiderocol susceptibility results include testing methods and standards used, making understanding resistance patterns crucial for treating patients suspected of Gram-negative infections with recent hospitalizations in Ukraine.
Objectives: This study aims to assess pharmacodynamic target attainment in critically ill patients and identify factors influencing target attainment and mortality outcomes.
Methods: We analysed data from the DOLPHIN trial. Beta-lactam and ciprofloxacin peak and trough concentration were measured within the first 36 h (T1) after initiation of treatment.
Radiotherapy in the head-and-neck area is one of the main curative treatment options. However, this comes at the cost of varying levels of normal tissue toxicity, affecting up to 80% of patients. Mucositis can cause pain, weight loss and treatment delays, leading to worse outcomes and a decreased quality of life.
View Article and Find Full Text PDFBackgroundThe war in Ukraine led to migration of Ukrainian people. Early 2022, several European national surveillance systems detected multidrug-resistant (MDR) bacteria related to Ukrainian patients.AimTo investigate the genomic epidemiology of New Delhi metallo-β-lactamase (NDM)-producing from Ukrainian patients among European countries.
View Article and Find Full Text PDFArticle Synopsis
- Model-informed precision dosing (MIPD) seeks to improve antibiotic treatment by using procalcitonin (PCT) levels as a biomarker for infection severity and antibiotic response.
- This study analyzed data from the DOLPHIN trial and examined PCT levels in critically ill patients at three time points (day 1, day 3, day 5) to see if MIPD led to better outcomes compared to standard dosing.
- Results showed no significant difference in PCT levels between MIPD and standard dosing groups, indicating that more research is needed to fully understand the potential benefits of using PCT to guide antibiotic dosing.