Publications by authors named "N J Stam"
Article Synopsis
- The study aimed to explore how variations in the unregulated drug market affect the risk of heroin overdose among individuals with differing personal overdose risk levels.
- Conducted over a year at the Medically Supervised Injecting Room in Melbourne, the research analyzed 1,474 overdose cases involving 337 participants, mostly male, with an average age of 43.5 years.
- Findings revealed that the overdose rate was significantly higher on days with high overdose risk, suggesting a 10-fold difference in daily overdose risk linked to market variations.
Aim: To differentiate the severity of acute opioid toxicity and describe both the clinical and physiological features associated with heroin overdose in a cohort of witnessed overdose cases.
Methods: Witnessed heroin overdose cases over a 12-month period (30 June 2018 - 30 June 2019) at the Medically Supervised Injecting Room (MSIR) in Melbourne, Australia were examined. The severity of acute opioid toxicity was classified according to the level of clinical intervention required to manage the overdose cases where an escalating level of care was provided.
Although clozapine treatment is often discontinued due to limited efficacy or low tolerability, there is a lack of guidelines and evidence on treatment options after discontinuation of clozapine in patients with schizophrenia. Persistence has proven to be an adequate indicator for treatment effectiveness in patients with schizophrenia. The aim of this study was, therefore, to compare persistence of antipsychotic use between antipsychotic treatment options in patients after stopping clozapine treatment.
View Article and Find Full Text PDFBackground: Although clozapine is often discontinued, there is a paucity of guidelines and evidence on treatment options after clozapine discontinuation. Moreover, it is currently unknown whether reinstating clozapine in patients formerly using clozapine should be avoided.
Aims: To compare the real-world effectiveness of antipsychotics after clozapine cessation.
Background: Accurate measurement of physical behaviour is paramount to better understand lifestyle, health, and functioning, particularly in adults with physical disability as they may be at higher risk of sedentary lifestyle and subsequent negative health consequences. This study aimed: 1) to evaluate the criterion validity of a novel and clinically applicable activity monitor (AM, Activ8), in the detection of body postures and movements in adults with spastic cerebral palsy (CP); and 2) to evaluate the extent that the AM's positioning affects validity.
Methods: In this cross-sectional study, 14 ambulatory adults with CP [9 men; mean (SD) age, 35.