Janus kinase (JAK) inhibitors block pathways involved in inflammation and immune response, making JAK inhibitors useful in the treatment of various diseases. While the efficacy of these drugs has been proven in several studies, their safety profile needs to be further investigated. In this systematic review and meta-analysis, we examined the risk of infections during treatment with oral JAK inhibitors with no concomitant treatment compared to placebo in phase 2 and 3 randomized, placebo-controlled trials.
View Article and Find Full Text PDFThis review underscores that psoriasis can manifest in infancy, negatively impacting the quality of life of children and their families. It often presents as minor, less pruritic plaques with subtle characteristics. Pediatric psoriasis is associated with an increased risk of arthritis, metabolic disorders, and psychological conditions, necessitating regular screenings.
View Article and Find Full Text PDFJ Psoriasis Psoriatic Arthritis
April 2024