Publications by authors named "N J S Loft"

Janus kinase (JAK) inhibitors block pathways involved in inflammation and immune response, making JAK inhibitors useful in the treatment of various diseases. While the efficacy of these drugs has been proven in several studies, their safety profile needs to be further investigated. In this systematic review and meta-analysis, we examined the risk of infections during treatment with oral JAK inhibitors with no concomitant treatment compared to placebo in phase 2 and 3 randomized, placebo-controlled trials.

View Article and Find Full Text PDF

This review underscores that psoriasis can manifest in infancy, negatively impacting the quality of life of children and their families. It often presents as minor, less pruritic plaques with subtle characteristics. Pediatric psoriasis is associated with an increased risk of arthritis, metabolic disorders, and psychological conditions, necessitating regular screenings.

View Article and Find Full Text PDF
Article Synopsis
  • Psoriasis is often linked with various health issues, including higher rates of obesity, which affects treatment choices and responses for affected individuals.
  • This study aimed to examine differences in patient characteristics among those starting or continuing biologic therapies for psoriasis and to assess the use of topical treatments after one year of therapy.
  • Findings revealed that younger patients with fewer instances of psoriatic arthritis were treated with ustekinumab, while most other patient factors remained consistent across different biologic treatments, indicating a need for more tailored treatment approaches.
View Article and Find Full Text PDF