Publications by authors named "N J Nagarajan"
Article Synopsis
- The study examines the relationship between skin oxylipins, which are bioactive lipids produced from fatty acids by skin microbes, and different microbial communities on the skin of children and adults.
- Findings highlighted that Malassezia restricta, a type of skin fungus, has a positive impact on the production of a specific oxylipin (9,10-DiHOME) in adults, while showing a negative correlation with its precursor in children, indicating differences in skin chemistry across age groups.
- The research suggests a complex communication system between skin microbes and host lipid metabolism that could have implications for skin health, emphasizing the need for further exploration of these interactions for potential therapeutic applications.
Article Synopsis
- - The study examines how different types of visual impairment (VI) in older adults relate to the likelihood of being hospitalized more than once, using data from a survey of Medicare recipients.
- - Results show that older adults with any type of VI have a higher probability of hospitalization, especially those with near VI, who are about twice as likely to be repeatedly hospitalized compared to those without visual issues.
- - The findings suggest that improving near vision may potentially reduce the chance of recurrent hospitalizations in seniors, indicating a need for further research on this topic.
Article Synopsis
- Poor vision (VI) may impact cognitive testing bias, which is critical to investigate, especially in regions with high VI prevalence and rising dementia concerns.
- The study analyzed data from 3,784 participants aged 60 and above, examining the influence of VI on cognitive performance across various domains while adjusting for demographics and health factors.
- Results indicate that although VI is linked to poorer cognitive scores, adjustments for potential bias show minimal impact on measurement differences, supporting that cognitive testing remains reliable despite VI presence.
While rapid demographic changes in Asia are driving the incidence of chronic aging-related diseases, the limited availability of high-quality in vivo data hampers our ability to understand complex multi-factorial contributions, including gut microbial, to healthy aging. Leveraging a well-phenotyped cohort of community-living octogenarians in Singapore, we used deep shotgun-metagenomic sequencing for high-resolution taxonomic and functional characterization of their gut microbiomes (n = 234). Joint species-level analysis with other Asian cohorts identified distinct age-associated shifts characterized by reduction in microbial richness, and specific Alistipes and Bacteroides species enrichment (e.
View Article and Find Full Text PDFEpidermal growth factor receptor (EGFR) gene mutations are prevalent in about 50% of lung adenocarcinoma patients. Highly effective tyrosine kinase inhibitors (TKIs) targeting the EGFR protein have revolutionized treatment for the prevalent and aggressive lung malignancy. However, the emergence of new EGFR mutations and the rapid development of additional drug resistance mechanisms pose substantial challenge to the effective treatment of NSCLC.
View Article and Find Full Text PDF