Fostering early adolescent health and planetary well-being through nature: a Delphi study on nature-based literacy.

Becoming nature 'literate' may promote nature engagement in early adolescence, supporting both health and well-being, while nurturing a sense of environmental stewardship. This study aimed to advance the formative research necessary for the development of a nature-based literacy framework including a set of indicators specific to its measurement during early adolescence. An e-Delphi study design was used with an expert panel comprised of international academics (n = 18) and practitioners (n = 8).

Prediction of future input explains lateral connectivity in primary visual cortex.

Neurons in primary visual cortex (V1) show a remarkable functional specificity in their pre- and postsynaptic partners. Recent work has revealed a variety of wiring biases describing how the short- and long-range connections of V1 neurons relate to their tuning properties. However, it is less clear whether these connectivity rules are based on some underlying principle of cortical organization.

Results from a UK consensus about the optimal prescribing of medium strength triple therapy in uncontrolled adult asthma patients in the NHS.

Context: An inhaled corticosteroid (ICS) in combination with a long-acting β2-agonist (LABA) is a common treatment approach for asthma patients not controlled on ICS alone, but a significant proportion of patients remain uncontrolled on this combination and treatment adherence can also be a challenge. One of the options for adults whose asthma is uncontrolled in an ICS/LABA is the addition of a long-acting muscarinic receptor antagonist (LAMA), an approach commonly referred to as 'triple therapy'. The use of medium-strength ICS/LABA/LAMA is established in treating chronic obstructive pulmonary disease but is less well-established in asthma.

Pol II degradation activates cell death independently from the loss of transcription.

Pol II-mediated transcription is essential for eukaryotic life. While loss of transcription is thought to be universally lethal, the associated mechanisms promoting cell death are not yet known. Here, we show that death following loss of Pol II is not caused by dysregulated gene expression.