Publications by authors named "N J Leeper"
Background: Smooth muscle cell (SMC) plasticity and phenotypic switching play prominent roles in the pathogenesis of multiple diseases, but their role in tumorigenesis is unknown. We investigated whether and how SMC diversity and plasticity plays a role in tumor angiogenesis and the tumor microenvironment.
Methods And Results: We use SMC-specific lineage-tracing mouse models and single cell RNA sequencing to observe the phenotypic diversity of SMCs participating in tumor vascularization.
Article Synopsis
- - Atherosclerosis is an inflammatory disease leading to heart issues, and enhancing the process of efferocytosis (cell removal by macrophages) is being explored as a potential treatment.
- - Blocking CD47, which signals cells not to be engulfed, reduces plaque buildup but can also cause anemia due to red blood cell clearance.
- - A new macrophage-specific nanotherapy was developed to promote efferocytosis without causing anemia, proving effective in early atherosclerosis models in pigs, showing promise for future treatments.
Background: Persistent chylomicronemia is a genetic recessive disorder that is classically caused by familial chylomicronemia syndrome (FCS), but it also has multifactorial causes. The disorder is associated with the risk of recurrent acute pancreatitis. Plozasiran is a small interfering RNA that reduces hepatic production of apolipoprotein C-III and circulating triglycerides.
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