Publications by authors named "N J Herrera"
Introduction: Paediatric tuberculosis (TB) underdiagnosis is a critical concern. The INPUT stepped-wedge cluster-randomised trial assessed the impact of integrating child TB services into child healthcare on TB case detection among children under age 5 years.
Methods: We compared the standard of care, providing TB care in specific TB clinics (control phase), with the Catalysing Paediatric TB Innovations (CaP-TB) intervention, integrating TB services across all child health services (intervention phase).
Background: In 2021, over one million children developed tuberculosis, resulting in 214 000 deaths, largely due to inadequate diagnosis and treatment. The diagnosis and treatment of tuberculosis is limited in most high-burden countries because services are highly centralised at secondary/tertiary levels and are managed in a vertical, non-integrated way. To improve case detection and treatment among children, the World Health Organisation (WHO) recommends decentralised and integrated tuberculosis care models.
View Article and Find Full Text PDFBackground: Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent childhood psychiatric condition with profound public health, personal, and family consequences. ADHD requires comprehensive treatment; however, lack of communication and integration across multiple points of care is a substantial barrier to progress. Given the chronic and pervasive challenges associated with ADHD, innovative approaches are crucial.
View Article and Find Full Text PDFIntroduction: Hypertension is prevalent in older women and men, but the impact of sex differences is unclear.
Methods: Blood pressure (BP) was evaluated weekly for 15 weeks using tail-cuff plethysmography in intact or gonadectomized female and male rats. Similarly, gonadectomized rats were subcutaneously treated daily for 15 weeks with estradiol in females or testosterone in males.
Article Synopsis
- The study investigates how highland and lowland deer mice adapt to varying levels of oxygen (hypoxia) at high elevations, focusing on phenotypic plasticity (ability to change) versus local adaptation (genetic specialization).
- The experiment involved progressively increasing hypoxia levels, simulating real-life elevation increases up to 6,000 meters, to assess the mice's aerobic thermogenesis.
- Findings show that highland mice have a genetic advantage, displaying better thermogenic performance under severe hypoxia, indicating that their ability to thrive in diverse environments comes from localized genetic adaptations and evolved responses to changing oxygen levels.