Publications by authors named "N J Fox"
Replications are important for assessing the reliability of published findings. However, they are costly, and it is infeasible to replicate everything. Accurate, fast, lower-cost alternatives such as eliciting predictions could accelerate assessment for rapid policy implementation in a crisis and help guide a more efficient allocation of scarce replication resources.
View Article and Find Full Text PDFHow well do plasma Alzheimer's disease biomarkers reflect the CSF amyloid status?
J Neurol Neurosurg Psychiatry
December 2024
Background: Can plasma biomarkers as well as cerebrospinal fluid (CSF) perform in the separation of amyloid-beta-positive (Aβ+) vs amyloid-beta-negative (Aβ-) groups across an age range seen in an NHS cognitive disorder clinic?
Methods: As part of the routine diagnostic investigation of 111 clinic patients who had contemporaneous blood and CSF samples taken, patients were categorised into Aβ+ and Aβ- groups based on their CSF in an Aβ42/40 ratio. We then evaluated four single molecule array (Simoa) Quanterix assays, quantifying single plasma analytes and ratios (p-tau217, p-tau217/Aβ42 ratio, p-tau181, p-tau181/Aβ42 ratio and Aβ42/40 ratio) in their ability to distinguish between these groups and the effect of age.
Results: The median (range) age of participants was 66 (55-79) years with 48 females (43.
Article Synopsis
- The study investigates the optical conductivity and magnetotransport properties of top-gated devices made from the topological insulator BiSe, focusing on how different carrier types within the material interact.
- Findings reveal that the topologically protected surfaces are somewhat shielded from gate control due to trivial band-bending states but still show significant mobility changes based on external gate bias.
- The research highlights that the optical conductivity is largely influenced by the topological surface states and is particularly affected by scattering from trivial states, suggesting potential uses in future plasmonic device designs.
A new perspective on the causal pathway between maternal mental health and neonatal adversity.
Arch Womens Ment Health
December 2024
Article Synopsis
- - The study investigates how maternal mental health affects birth outcomes, particularly looking at complications and congenital anomalies in newborns, while accounting for maternal physical health and family background.
- - Using data from over 74,000 children born between 1997-2008 in Israel, the researchers found significant links between maternal mental health issues during pregnancy and negative neonatal outcomes, although these links weakened when considering maternal physical health.
- - The findings suggest that both maternal and paternal mental health diagnoses independently contribute to adverse birth outcomes, highlighting the importance of addressing physical health and family dynamics in understanding these associations.
Introduction: Alzheimer disease (AD)-modifying therapies are approved for treatment of early-symptomatic AD. Autosomal dominant AD (ADAD) provides a unique opportunity to test therapies in presymptomatic individuals.
Methods: Using data from the Dominantly Inherited Alzheimer Network (DIAN), sample sizes for clinical trials were estimated for various cognitive, imaging, and CSF outcomes.