A randomised controlled trial of the clinical effectiveness and cost-effectiveness of different knee prostheses: the Knee Arthroplasty Trial (KAT).

Background: In the late 1990s, new developments in knee replacement were identified as a priority for research within the NHS. The newer forms of arthroplasty were more expensive and information was needed on their safety and cost-effectiveness.

Objectives: The Knee Arthroplasty Trial examined the clinical effectiveness and cost-effectiveness of four aspects of knee replacement surgery: patellar resurfacing, mobile bearings, all-polyethylene tibial components and unicompartmental replacement.

Impact of change of knee prosthesis on early clinical outcomes in a large volume arthroplasty centre.

Introduction: The aim of our study was to investigate the effect of changing the default knee prosthesis in a high volume dedicated arthroplasty unit from DePuy's PFC(®) Sigma(®) to Smith & Nephew's Genesis™ II.

Methods: A retrospective analysis was performed of prospective data on primary total knee replacements (TKRs) from January 2009 until December 2011. This provided information on the operative time, length of stay, pain at mobilisation, radiography analysis, any complications, and readmission at 30 and 60 days.

Five-year results of a randomised controlled trial comparing mobile and fixed bearings in total knee replacement.

There is conflicting evidence about the merits of mobile bearings in total knee replacement, partly because most randomised controlled trials (RCTs) have not been adequately powered. We report the results of a multicentre RCT of mobile versus fixed bearings. This was part of the knee arthroplasty trial (KAT), where 539 patients were randomly allocated to mobile or fixed bearings and analysed on an intention-to-treat basis.

Does malrotation of components correlate with patient dissatisfaction following secondary patellar resurfacing?

Background: The aim of our study was to identify whether there was any correlation between the outcome of secondary patellar resurfacing and malrotation of either the femoral or tibial component.

Methods: We identified patients that underwent secondary patellar resurfacing following previous primary total knee arthroplasty (TKA) at a single, large orthopaedic department. Patients were reviewed for range of movement, satisfaction, health status and knee function.

Patellar resurfacing in total knee replacement: five-year clinical and economic results of a large randomized controlled trial.

Background: There is conflicting evidence regarding the merits of patellar resurfacing during total knee arthroplasty, as many of the previous randomized controlled trials have not been adequately powered.

Methods: A pragmatic, multicenter, randomized controlled trial was initiated in 1999 in the United Kingdom. Within a partial factorial design, 1715 patients were randomly allocated to receive or not receive patellar resurfacing during total knee arthroplasty.