Publications by authors named "N J Day"
Antimicrobial resistance (AMR) is predicted to outstrip malaria, HIV, and tuberculosis combined as the leading infectious cause of death by 2050. Strengthening the knowledge and evidence base for AMR with surveillance and research is one of the five main objectives of the WHO Global Action Plan on AMR. While recent efforts to strengthen diagnosis and surveillance have been encouraging, these are unlikely to be sustainable without continued funding support in most low-resource settings.
View Article and Find Full Text PDFThe emergence of Plasmodium falciparum parasites resistant to artemisinins compromises the efficacy of Artemisinin Combination Therapies (ACTs), the global first-line malaria treatment. Artemisinin resistance is a complex genetic trait in which nonsynonymous SNPs in PfK13 cooperate with other genetic variations. Here, we present population genomic/transcriptomic analyses of P.
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- * The patient underwent extensive treatment, including multiple procedures and medications, achieving remission with a combination of swallowed steroids and high-dose proton pump inhibitors (PPIs), but faced a relapse when attempting to reduce PPI use.
- * This case highlights the potential benefits of genetic testing for patients with hard-to-treat EoE and raises important questions about treatment strategies and goals for affected children with genetic mutations.
Climate change intensifies fires, raising questions about their impacts on plant invasions via changes in soil biota and plant-soil feedback (plants alter soil conditions, changing plant growth and vice-versa). We explored effects of plant-soil feedback and simulated fire (heat) on mutualistic arbuscular mycorrhizal (AM) fungal communities and invasive plant growth. Soils were collected from a dominant native grass () and two invasive hawkweeds (, ) in a New Zealand grassland and then heated.
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- Understanding protein function requires exploring how various posttranslational modifications (PTMs) work together, but existing methods often struggle to analyze multiple PTMs from a single sample.
- The single-pot, solid-phase-enhanced sample preparation (SP3) method streamlines the process, making it easier to analyze protein abundance and different PTMs like phosphorylation and acetylation simultaneously.
- This SP3 workflow shows promise in a study of β-cells treated with cytokines, revealing rapid protein abundance changes and complex interactions among regulatory pathways, which could help clarify how PTMs influence cellular responses over time.