Publications by authors named "N J Conrad"
Paeniclostridium sordellii is responsible for severe infections in horses, cattle, and sheep, however, conventional vaccines exhibit limitations in production and immunogenicity. This study assessed the immunogenicity of a recombinant bacterin composed of a chimera (rQTcsHL) that combines segments from the lethal (TcsL) and hemorrhagic (TcsH) toxins in mice and sheep. Both immunized animal groups exhibited elevated levels of IgG, with the mice demonstrating moderate protection (<50 %) against lethal challenges, comparable to that of the conventional vaccine.
View Article and Find Full Text PDFBackground: Heart failure is common, complex, and often associated with coexisting chronic medical conditions and a high mortality. We aimed to assess the epidemiology of people admitted to hospital with heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), including the period covering the COVID-19 pandemic, which was previously not well characterised.
Methods: In this retrospective, cohort study, we used whole-population electronic health records with 57 million individuals in England to identify patients hospitalised with heart failure as the primary diagnosis in any consultant episode of an in-patient admission to a National Health Service (NHS) hospital.
O-GlcNAcylation is the reversible post-translational addition of β-N-acetylglucosamine to serine and threonine residues of nuclear and cytoplasmic proteins. It plays an important role in several cellular processes through the modification of thousands of protein substrates. O-GlcNAcylation in humans is mediated by a single essential enzyme, O-GlcNAc transferase (OGT).
View Article and Find Full Text PDFRomanisation is a multi-faceted historical phenomenon with profound and lasting cultural impact on the ancient world. In the modern-day territory of Tunisia, this is particularly manifest during the first four centuries AD, under the reign of the Roman Empire. We derive a reduced, operational concept of Romanisation as a cultural diffusion process that is observable in the archaeological remains of the Roman era settlement system.
View Article and Find Full Text PDFArticle Synopsis
- The study looked at two ways to close a hole in the heart called a patent foramen ovale (PFO) to prevent blood clots, using either fluoroscopy (FS) or both fluoroscopy and transesophageal echocardiography (TOE) for guidance.
- They analyzed 203 patients and found that using FS alone was faster, but both methods achieved similar success rates in closing the PFO at 6 months.
- No significant differences were found in complications or reoccurring heart issues between the two methods, suggesting FS-only guidance is just as effective as using both TOE and FS.