Publications by authors named "N J Chong"
Article Synopsis
- Diabetic nephropathy (DN) is a common complication of diabetes, and Colquhounia Root Tablet (CRT) has shown potential therapeutic effects, although its mechanisms are not fully understood.
- Using various databases, researchers identified 163 therapeutic targets of CRT related to DN and found key targets like STAT3 and IL6 through protein-protein interaction analysis.
- The study highlighted the AGEs/RAGE signaling pathway as significant for CRT's effectiveness against DN and confirmed its protective effects on kidney cells via experimental treatments, although further studies are required to assess the safety and efficacy in real-life scenarios.
Article Synopsis
- This study explores the effectiveness of a two-dimensional gas chromatography-flame ionization detection (GC×GC-FID) method for identifying 12 psychoactive drugs in urine, including popular substances like cocaine and methamphetamine.
- The method achieved clear separation of these drugs within 8 minutes using a specific column setup, demonstrating better results than traditional configurations.
- Validation showed high accuracy and precision for drug detection, with very low detection limits and effective recovery rates, proving its usefulness for quick forensic drug testing.
It has been shown that magnetic resonance imaging (MRI) guidance versus computed tomography (CT) guidance for aggressive margin-reduction (AMR) for stereotactic body radiotherapy (SBRT) in prostate cancer reduces acute toxicity, but the longer-term benefits are unknown. We performed a secondary analysis of MIRAGE, a phase 3 randomized clinical trial of MRI-guided SBRT for prostate cancer, to determine whether AMR with MRI guidance significantly reduced 2-yr physician-scored or patient-reported toxic effects in comparison to CT guidance. The cumulative incidence of 2-yr physician-scored toxicity, defined as grade ≥2 genitourinary (GU) and gastrointestinal (GI) toxic effects according to Common Terminology Criteria for Adverse Events v4.
View Article and Find Full Text PDFNavigating ChatGPT's alignment with expert consensus on pediatric OSA management.
Int J Pediatr Otorhinolaryngol
November 2024
Objective: This study aimed to evaluate the potential integration of artificial intelligence (AI), specifically ChatGPT, into healthcare decision-making, focusing on its alignment with expert consensus statements regarding the management of persistent pediatric obstructive sleep apnea.
Methods: We analyzed ChatGPT's responses to 52 statements from the 2024 expert consensus statement (ECS) on the management of pediatric persistent OSA after adenotonsillectomy. Each statement was input into ChatGPT using a 9-point Likert scale format, with each statement entered three times to calculate mean scores and standard deviations.
Article Synopsis
- Mutations are crucial for gene research across all forms of life, especially for identifying genes linked to asexual spore development in fungi.
- Researchers isolated mutants of the fungus Paecilomyces variotii, which cannot produce the yellow pigment due to mutations in specific genes (pvpP, abaA, and wetA) that are essential for pigment and spore development.
- The WetA protein, which is crucial for spore development, localizes in the nuclei of spores and functions as a transcription regulator, with differences in the impact of the related gene module among various fungal species.