Publications by authors named "N J Camp"
Background: The 313-variant polygenic risk score (PRS) provides a promising tool for clinical breast cancer risk prediction. However, evaluation of the PRS across different European populations which could influence risk estimation has not been performed.
Methods: We explored the distribution of PRS across European populations using genotype data from 94,072 females without breast cancer diagnosis, of European-ancestry from 21 countries participating in the Breast Cancer Association Consortium (BCAC) and 223,316 females without breast cancer diagnosis from the UK Biobank.
Article Synopsis
- Spontaneous preterm birth (SPTB) is a major cause of health issues in newborns and can arise from various unknown genetic factors, prompting the need for better understanding through family studies.
- The research utilized the Utah Population Database to identify large families with multiple cases of early SPTB and focused on seven specific pedigrees for genetic analysis, excluding other known causes of preterm birth.
- The study discovered two significant chromosomal regions related to SPTB, particularly in chromosome 8 (8q24.23), suggesting potential genetic markers for this condition.
Article Synopsis
- The study investigates how older adults, particularly those with low socioeconomic status and motor impairments, view social assistive robots (SARs) and monitoring technologies to help with daily activities and minimize inactivity.
- Using focus groups and surveys, researchers identified themes related to technology use, perceived barriers, preferences, and current technology use among different groups of older adults.
- Findings suggest that lower physical well-being correlates with greater interest and perceived usefulness of SARs, while those with low socioeconomic status feel they have less control over these technologies compared to others.
Identification of Individuals With Hereditary Cancer Risk Through Multiple Data Sources: A Population-Based Method Using the GARDE Platform and The Utah Population Database.
JCO Clin Cancer Inform
November 2024
Purpose: The GARDE platform uses family history reported in the electronic health record (EHR) to systematically identify eligible patients for genetic testing for hereditary cancer syndromes. The goal of this study was to evaluate the change in effectiveness of GARDE to identify eligible individuals when more comprehensive family history data are provided, thus quantifying the impact of underdocumentation.
Methods: A cohort of 133,764 patients at the University of Utah Health was analyzed with GARDE comparing identification rates using EHR data versus EHR plus data from a statewide population database, the Utah Population Database (UPDB).