Publications by authors named "N J Buckley"
Human induced pluripotent stem cells (iPSCs) provide powerful cellular models of Alzheimer's disease (AD) and offer many advantages over non-human models, including the potential to reflect variation in individual-specific pathophysiology and clinical symptoms. Previous studies have demonstrated that iPSC-neurons from individuals with Alzheimer's disease (AD) reflect clinical markers, including β-amyloid (Aβ) levels and synaptic vulnerability. However, despite neuronal loss being a key hallmark of AD pathology, many risk genes are predominantly expressed in glia, highlighting them as potential therapeutic targets.
View Article and Find Full Text PDFObjective: Early antivenom administration is essential for effective treatment. We investigated the delays in antivenom administration.
Methods: We reviewed snakebites from the Australian Snakebite Project (2006-2021) given antivenom, presenting to hospital within 12 h.
This article explores dementia care in Japan's aging population with a focus on mitigating social isolation and loneliness in older adults with dementia. Through an in-depth examination of case studies, the study highlights several community-based interventions, including Community Cafés, the Dementia Supporter Caravan, and the Omuta City Dementia Care model. These cases provide insights into how these initiatives foster community engagement and inclusive environments.
View Article and Find Full Text PDFAims: To compare a low-dosing protocol to standard practice for methadone-buprenorphine transfers.
Methods: We undertook a nonrandomized open-label clinical trial across 8 sites from NSW, Australia. Participants prescribed methadone wishing to transfer to buprenorphine could either choose or be randomized to a low-dose transfer or standard care transfer as per NSW health guidelines.
Article Synopsis
- - The study investigates how tendon maturation into strong tissue is regulated, noting significant mechanical property changes in chick embryos between days E16 and E18, but lacking clarity on the underlying cellular and molecular factors.
- - Researchers analyzed late tendon development by examining collagen fiber alignment, cell organization, and Yap pathway activity, assessing the impact of both constant loading and no loading on tendon maturation.
- - Findings revealed that YAP signaling is influenced by movement, with collagen alignment improving under static loading; however, immobilization disrupted the organized structure of tendon cells, highlighting the importance of dynamic stimulation for proper tendon development.