Publications by authors named "N J Basma"
Objective: Lennox-Gastaut Syndrome (LGS) is a severe, often treatment-resistant epilepsy syndrome typically diagnosed in early childhood. Many have seizures before diagnosis. Some have periods of seizure freedom before treatment resistance, i.
View Article and Find Full Text PDFSmooth muscle cells (SMCs), Interstitial cells of Cajal (ICC) and Platelet-derived growth factor receptor α positive (PDGFRα) cells form an integrated, electrical syncytium within the gastrointestinal (GI) muscular tissues known as the SIP syncytium. Immunohistochemical analysis of gastric corpus muscles showed that c-KIT/ANO1 ICC-IM and PDGFRα cells were closely apposed to one another in the same anatomical niches. We used intracellular microelectrode recording from corpus muscle bundles to characterize the roles of intramuscular ICC and PDGFRα cells in conditioning membrane potentials of gastric muscles.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to estimate the incidence of 28 rare epilepsies in children from New York City between 2010-2014 and compare these findings with existing literature.
- - Eight of the rare epilepsies had multiple prior estimates, and the researchers' findings were consistent with published data, identifying infantile epileptic spasms as the most common, while 15 had less data, resulting in new estimates for conditions like early infantile developmental encephalopathy.
- - The findings highlight a gap in research, particularly for genetic epilepsies with vague symptoms, suggesting the need for more comprehensive studies to clarify their incidence.
CCS1477 (inobrodib) is a potent, selective EP300/CBP bromodomain inhibitor which induces cell-cycle arrest and differentiation in hematologic malignancy model systems. In myeloid leukemia cells, it promotes rapid eviction of EP300/CBP from an enhancer subset marked by strong MYB occupancy and high H3K27 acetylation, with downregulation of the subordinate oncogenic network and redistribution to sites close to differentiation genes. In myeloma cells, CCS1477 induces eviction of EP300/CBP from FGFR3, the target of the common (4; 14) translocation, with redistribution away from IRF4-occupied sites to TCF3/E2A-occupied sites.
View Article and Find Full Text PDFObjective: Administrative codes to identify people with rare epilepsies in electronic health records are limited. The current study evaluated the use of keyword search as an alternative method for rare epilepsy cohort creation using electronic health records data.
Methods: Data included clinical notes from encounters with International Classification of Diseases, Ninth Revision (ICD-9) codes for seizures, epilepsy, and/or convulsions during 2010-2014, across six health care systems in New York City.