Clostridium Difficile Associated Disease: Burden of and Predictors for in Hospital Fatal Outcome. Results of a Hospital-Based Study, Bucharest, Romania.

Introduction: In the last 15 years Clostridium difficile infection became a typical new emergent threat worldwide. Our aim was to describe the risk factors associated with fatal outcome of Clostridium difficile associated disease (CDAD) cases treated in 2012 in "Dr Victor Babes" Infectious and Tropical Diseases Hospital, a 450 beds teaching clinic from Bucharest, Romania.

Material And Methods: Retrospective cohort study - the case records of hospitalized patients in the year 2012, presenting with diarrhea and that tested positive for C difficile through toxin A and B assays were reviewed.

Procalcitonin, and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites.

Aim: To quantitate the simultaneous serum and ascitic fluid levels of procalcitonin and inflammatory markers in cirrhotics with and without ascites.

Methods: A total of 88 consecutive severe cirrhotic patients seen in a large city hospital liver clinic were studied and divided into two groups, those with and without ascites. Group 1 consisted of 41 cirrhotic patients with massive ascites, as demonstrated by necessity for therapeutic large-volume paracentesis.

Disease dependent qualitative and quantitative differences in the inflammatory response to ascites occurring in cirrhotics.

Aim: To assess differing patterns and levels of ascitic fluid cyctokine and growth factors exist between those with a high risk and low risk of spontaneous bacterial peritonitis (SBP).

Methods: A total of 57 consecutive patients with ascites requiring a large volume paracentesis were studied. Their age, gender, specific underlying disease conditions were recorded after a review of their clinical records.

Plasma triglyceride levels may modulate hepatitis C viral replication.

Background: Plasma and hepatic lipid abnormalities are frequent in hepatitis C infected individuals.

Methods: Plasma lipid and medical records profiles were prospectively obtained in 130 consecutive individuals seen by a single hepatologist in a university liver disease clinic. The relationships between viral load, genotype, plasma lipid fractions, HDL, LDL particle number and particle size were examined.

[Effect of systematic vaccination on the epidemiology of urlian parotiditis in the population of Bucharest].

Objective: describe the mumps evolution during the time period that immediately followed the introduction of routine mumps vaccine into the Bucharest municipality's population.

Methods: observational, descriptive, and retrospective study. The temporal frequencies were taken from official reports of clinically confirmed mumps cases with annually sequence during the 1951-2001 period and monthly sequence during the 2002-2009 period of time respectively.