Publications by authors named "N Improda"
Comparison between Friedewald's and Sampson's formulas in the estimation of high levels of measured LDL-cholesterol in youth with obesity.
Procolo Di Bonito Domenico Corica Malgorzata Gabriela Wasniewska Anna Di Sessa Emanuele Miraglia Del Giudice Nicola Improda
Nutr Metab Cardiovasc Dis
September 2024
Article Synopsis
- The study evaluated Friedewald's and Sampson's formulas for measuring LDL-Cholesterol (LDL-C) in overweight and obese youths aged 5-17 in Italy, involving a total of 1,694 participants from two centers.
- Results indicated that both formulas were highly accurate in estimating LDL-C levels, with comparable sensitivity and specificity, though Friedewald's formula had a higher positive predictive value.
- The authors concluded that calculated LDL-C is a practical tool for screening adolescents, particularly favoring Friedewald's formula due to its simplicity in clinical settings.
Article Synopsis
- Glucocorticoids (GCs) are widely used in treating various pediatric conditions, but long-term use can lead to adrenal insufficiency (GI-AI), which is often overlooked, especially with non-systemic formulations.
- The review analyzes the impact of chronic GC treatments on the hypothalamic-pituitary-adrenal (HPA) axis and highlights the importance of carefully tapering off GCs to prevent life-threatening conditions like adrenal crisis (AC).
- The findings stress the need for better understanding and management strategies for GI-AI in children, including monitoring cortisol levels and adjusting treatment to minimize risks associated with steroid withdrawal.
Article Synopsis
- Prader-Willi syndrome (PWS) is a genetic disorder caused by different problems on chromosome 15, affecting how some genes work.
- People with PWS often feel super hungry all the time, can become very overweight, and may have other health and learning issues.
- The review explores how different genetic causes of PWS can lead to specific health problems and looks for ways to improve diagnosis and treatments for those affected.
Perinatal asphyxia and hypothermic treatment from the endocrine perspective.
Front Endocrinol (Lausanne)
November 2023
Article Synopsis
- - Perinatal asphyxia significantly contributes to neonatal death and health issues, with therapeutic hypothermia being the standard treatment that reduces mortality and major developmental disabilities.
- - Endocrine-related problems, such as glucose and electrolyte imbalances or adrenal complications, can arise in infants experiencing perinatal asphyxia, potentially impacting their health outcomes.
- - Clinicians need to recognize the potential endocrine complications in asphyxiated infants to implement effective screening and timely interventions for improving overall outcomes.
Article Synopsis
- Growth hormone deficiency (GHD) in children is linked to cardiovascular issues, which can improve with growth hormone (GH) treatment; however, research on this topic is limited.
- A study involving 24 GHD children and 24 matched controls showed that GHD children had worse lipid profiles and higher body fat ratios, but these indicators improved significantly after one year of GH therapy.
- The findings suggest that GHD children experience early signs of endothelial dysfunction and atherosclerosis, but GH treatment helps to reverse these conditions, showcasing the importance of addressing GHD promptly.