Publications by authors named "N Imahashi"
Background: To investigate whether the addition of eltrombopag (EPAG) to rabbit anti-thymocyte globulin (ATG)-based immunosuppressive therapy (IST) for newly diagnosed severe aplastic anemia (SAA) improves outcomes and affects the cumulative incidence of clonal evolution (CE), we conducted a multicenter retrospective analysis.
Methods: Data were collected from 101 patients, aged 15 - 65 years, undergoing initial IST.
Results: No significant imbalance in age, sex, or severity was observed between the EPAG (n = 20) and non-EPAG (n = 81) groups.
Article Synopsis
- Fludarabine-based conditioning regimens in cord blood transplantation (CBT) have varying effectiveness, with the study analyzing five different combinations in 1395 adult patients suffering from myeloid malignancies.
- The results showed that the combination of fludarabine and melphalan with high-dose total body irradiation (FM140T) had the highest 3-year survival rate (67%), while other regimens had significantly lower rates, indicating FM140T as the most favorable option.
- These outcomes suggest that survival rates in CBT for myeloid cancers depend greatly on the type and dosage of alkylating agents used alongside fludarabine, with FM140T being recommended over fludarabine/busulfan
Background: We conducted a retrospective study to categorize the cord blood unit (CBU)s to identify the optimal units.
Methods: A total of 8503 adults (female, n = 3592; male, n = 4911) receiving their first single cord blood transplantation (CBT) in 2000-2019 were analyzed. Factors associated with CBUs affecting overall survival (OS) and neutrophil engraftment were selected to create ranked categorization for each outcome, followed by comparison with transplantation using HLA-matched bone marrow (BMT)/peripheral blood stem cell (PBSCT) from unrelated (n = 6052) and related donors (n = 4546).
Umbilical cord blood (UCB) is a valuable alternative donor source for allogeneic hematopoietic stem cell transplantation. Various conditioning regimens and graft-versus-host disease (GVHD) prophylaxis regimens aimed at improving the outcomes of umbilical cord blood transplantation (UCBT) have been explored; however, the differences in their effects remain unclear. This study was conducted to elucidate the differences in the effects of conditioning and GVHD prophylaxis regimens on UCBT outcomes by disease type in a nationwide, retrospective study.
View Article and Find Full Text PDFA 55-year-old man in first complete remission of acute myeloid leukemia with a normal karyotype underwent allogeneic hematopoietic stem cell transplantation from a human-leukocyte-antigen-matched sibling. Bone marrow examination on day 28 confirmed complete remission, but G-banding analysis revealed a novel chromosomal abnormality, including dic(18;20)(p11.2;q11.
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