Publications by authors named "N Ikonen"
Article Synopsis
- The study addresses the challenge of treating advanced cancers, where cellular diversity requires therapies targeting multiple cancer cell populations.* -
- A machine learning tool called scTherapy uses single-cell transcriptomic data to identify personalized multi-targeting treatment options for patients with various cancers, like acute myeloid leukemia and ovarian carcinoma.* -
- Results show that 96% of the proposed treatments are effective and selective for cancer cells, with 83% having low toxicity to healthy cells, suggesting a promising avenue for safer and more effective cancer therapies.*
Article Synopsis
- Highly pathogenic avian influenza (HPAI A(H5N1)) caused high mortality rates among wild and domestic birds in Europe from 2020 to 2023, notably spreading to fur farms in Finland in July 2023.
- The virus was detected in animals like silver and blue foxes, minks, and raccoon dogs, showing severe health issues and mutations that may help it adapt to mammalian hosts.
- Close cooperation between animal and human health authorities was necessary to manage the outbreak and to address potential health impacts, as the virus was linked to mass bird die-offs and vulnerable farm biosecurity practices.
Despite its popularity for water activities, such as swimming, surfing, fishing, and rafting, inland and coastal bathing areas occasionally experience outbreaks of highly pathogenic avian influenza virus (HPAI), including A(H5N1) clade 2.3.4.
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- Enterovirus D68 (EV-D68) infections can cause severe respiratory issues and acute flaccid myelitis, with a significant rise reported during the fall-winter season of 2021-2022 across Europe.
- The study by the European Non-Polio Enterovirus Network (ENPEN) analyzed over 10,481 samples from 19 countries, identifying 1,004 as EV-D68, predominantly affecting young children, where 37.9% required hospitalization.
- Additionally, genetic analyses uncovered two new B3-derived lineages without regional patterns, indicating a notable impact of the infections and the emergence of new virus strains.
Monosomy 7 and del(7q) (-7/-7q) are frequent chromosomal abnormalities detected in up to 10% of patients with acute myeloid leukemia (AML). Despite unfavorable treatment outcomes, no approved targeted therapies exist for patients with -7/-7q. Therefore, we aimed to identify novel vulnerabilities.
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