Publications by authors named "N I Zakharova"
Bacterial infections have accompanied humanity for centuries. The discovery of the first antibiotics and the subsequent golden era of their discovery temporarily shifted the balance in this confrontation to the side of humans. Nevertheless, the excessive and improper use of antibacterial drugs and the evolution of bacteria has gotten the better of humans again.
View Article and Find Full Text PDFThe active and widespread transition to distance learning modalities was prompted by the COVID-19 pandemic and is currently considered a prospective paradigm for the development of the education system. This shift necessitates the creation of corresponding curricula and programs capable of fostering student competencies through online and blended learning. The purpose of this research is to examine the specifics and formulate an algorithm for the development of educational programs incorporating distance and blended learning technologies.
View Article and Find Full Text PDFTuberculosis is a deadly bacterial disease and the second most common cause of death from monoinfectious diseases worldwide. Comprehensive measures taken by health authorities in various countries in recent decades have saved tens of millions of lives, but the number of new cases of this infection has been steadily increasing in the last few years and already exceeds 10 million new cases annually. The development of new vaccines against tuberculosis is a priority area in the prevention of new cases of the disease.
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- Accumulation of beta-amyloid peptides (Aβ) and their modifications, particularly phosphorylated serine-8 (pSer8-Aβ), are key factors in the progression of Alzheimer's disease (AD), influencing neuronal degradation and cytotoxicity.* -
- The study found that pSer8-Aβ levels in the brains of 5xFAD mice steadily increase from 3 months to 14-17 months, paralleling the general accumulation of Aβ peptides, and that pSer8-Aβ constitutes up to 1-10% of total Aβ in the cerebrospinal fluid of AD patients.* -
- Mass spectrometry confirmed the possibility of specific Aβ phosphorylation in brain tissues, suggesting
Background/objectives: The development of blood tests for the early detection of individual predisposition to socially significant diseases remains a pressing issue.
Methods: In this pilot study, multiple reaction monitoring mass spectrometry (MRM-MS) with a BAK-270 assay was applied for protein concentrations analysis in blood plasma from 21 healthy volunteers of the European cohort.
Results: The levels of 138 plasma proteins were reliably and precisely quantified in no less than 50% of samples.