Publications by authors named "N I Volkova"
Obesity is associated with changes in the gut microbiota, as well as with increased permeability of the intestinal wall. In 130 non-obese volunteers, 57 patients with metabolically healthy obesity (MHO), and 76 patients with metabolically unhealthy obesity (MUHO), bacterial DNA was isolated from stool samples, and the 16S rRNA gene was sequenced. The metabolic profile of the microbiota predicted by PICRUSt2 (https://huttenhower.
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- A genome-wide association study (GWAS) was conducted on a rooster population to identify single nucleotide polymorphisms (SNPs) and candidate genes linked to growth and meat productivity traits.
- The study involved crossing two chicken breeds with different growth rates, using advanced genotyping methods, which resulted in the analysis of over 54,000 SNPs.
- The research identified significant SNPs associated with body weight and meat quality traits, suggesting that these can be used as genetic markers to enhance broiler production and breeding efforts.
A new genus and species of fossil swallows, Miochelidon eschata gen. et sp. nov.
View Article and Find Full Text PDFSqualene-based adjuvant compositions that can provide effective induction of specific humoral immune response have been developed. Recombinant receptor-binding domain (RBD) of surface S-protein of SARS-CoV-2 was used to evaluate the properties of the composition. Immunization of mice with the developed squalene-based compositions in combination with RBD allows obtaining high titers of specific antibodies: from 10 to 2×10.
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- The rise of filovirus outbreaks in Africa has created an urgent need for effective antiviral treatments.
- Researchers synthesized and tested various derivatives of two compounds, (+)-fenchol and (-)-isopinocampheol, discovering that those with an N-alkylpiperazine cycle showed the strongest antiviral activity against specific viruses.
- The antiviral effects of these compounds likely come from their ability to bind to surface glycoproteins of the viruses and their lysosomotropic properties, indicating they could potentially be dual-action agents worth further investigation.