[Comparative analysis of morphofunctional indicators of peritoneal macrophages in mice of the cancer line A/SN and white outbred mice].

A study of the functional state of peritoneal macrophages was conducted of white outbred mice (W/o) which were resistant to cancer pathology as well as the mice of the A/sn line prone to development of cancer diseases. It was reveald that due to induction of aseptic inflammation ( induced by starch administration), chemotaxis of macrophages of the oncological line was 2.5-3 times reduced and capacity to adhesion was 1.

[Placentofetal relations as a basis for development and differentiation of definitive organs and tissues].

On the basis of the analysis of clinical and experimental data a conclusion is made about existence of the regulatory-metabolic relations between different elements of the placenta and organs and tissues of the fetus which determine adaptive and pathological reactions in developing fetus. Regulation of metabolic relationships is a necessary part of systemogenesis and after development of the definitive cells and functional systems blocks the correlative systems. This mechanism is very important for development of the regulatory systems of the fetus forming postnatal homeostasis.

[Effect of adrenalectomy in pregnant mice on activity and spectrum of alkaline phosphomonoesterase in placenta and fetal organs].

Unilateral adrenalectomy in mice on pregnancy day 14 stimulates activity of alkaline phosphomonoesterase in placenta on pregnancy day 21. This is often accompanied with changes in the enzyme activity in fetal liver, kidneys, bone, intestine. Additional isoforms of alkaline phosphomonoesterase appear in the electrophoretic spectrum.

[Electrophoretic alkaline phosphatase isoforms in the placenta in complicated pregnancy].

A clinical study showed that 2 types of changes in electrophoretic spectrum of alkaline phosphatase (AIP) isoforms are distinguished in the chorion of delivered placenta after gestosis. In type I new AIP isoforms appear, while in type II some AIP isoforms disappear or are united in one, which reflects the development of adaptation or pathological processes in the fetoplacental system.

Role of placenta in the regulation of fetal erythropoiesis.

We studied erythropoiesis in newborn infants delivered by mothers with normal pregnancy and gestosis. The effects of placental extracts on hemopoiesis in JCR mice were also evaluated. Our results suggest that the placenta is involved in the regulation of fetal erythropoiesis.