Publications by authors named "N I Stavropoulos"
Mutations of the Cullin-3 (Cul3) E3 ubiquitin ligase are associated with autism and schizophrenia, neurological disorders characterized by sleep disturbances and altered synaptic function. Cul3 engages dozens of adaptor proteins to recruit hundreds of substrates for ubiquitination, but the adaptors that impact sleep and synapses remain ill-defined. Here we implicate Insomniac (Inc), a conserved protein required for normal sleep and synaptic homeostasis in Drosophila, as a Cul3 adaptor.
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- Tenosynovial giant cell tumor (TGCT) is a rare benign tumor that can aggressively affect joints and tendons, with two main types: localized (L-TGCT) and diffuse (D-TGCT).
- Surgical removal is the primary treatment method; however, D-TGCT has a high chance of recurring, which raises the need for other treatment options.
- Recent studies highlight that while surgery remains the best approach, additional systemic therapies are increasingly used for cases that return or don't respond to surgery.
Article Synopsis
- Degenerative cervical myelopathy (DCM) is a major cause of spinal cord dysfunction in adults, leading to significant health issues and financial costs, with most patients requiring surgery eventually.
- The review examines various pharmacological agents that might help treat mild DCM or improve surgical results, highlighting mixed evidence for effectiveness in both human and animal studies.
- Key findings indicate that while some drugs like Riluzole and Cerebrolysin show potential in animal studies, their benefits in humans are inconclusive, and more robust clinical data is needed to explore new neuroprotective therapies for DCM.
Mutations in Cullin-3 (Cul3), a conserved gene encoding a ubiquitin ligase, are strongly associated with autism spectrum disorder (ASD). Here, we characterize ASD-related pathologies caused by neuron-specific Cul3 knockdown in Drosophila. We confirmed that neuronal Cul3 knockdown causes short sleep, paralleling sleep disturbances in ASD.
View Article and Find Full Text PDFBackground: The number of total knee arthroplasty (TKA) procedures performed annually is increasing for reasons not fully explained by population growth and increasing rates of obesity. The purpose of this study was to determine the role of patient functional status as an indication for surgery and to determine if patients are undergoing surgery with a higher level of preoperative function than in the past.
Methods: A systematic review and meta-analysis of the MEDLINE, Embase and Cochrane databases was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.