PREDICTION OF THE RISKS OF THE DEVELOPMENT OF COMORBIDITY OF CORONARY HEART DISEASE AND OBESITY IN THE BACKGROUND OF MILITARY ACTIONS.

Objective: The aim: Study of prognostic possibilities of batokine complexes (fibroblast growth factor (FGF-21) and vascular endothelial growth factor A (VEGF-A)) in determining the risks of developing coronary heart disease (CHD) and obesity (especially in case of their comorbidity).

Patients And Methods: Materials and methods: 105 patients aged 25-85 were examined: 70 (main group) -with CHD on the background of obesity and 35 - with isolated CHD (comparison group).

Results: Results: Probable associations with increased risks of comorbidity of CHD and obesity were: increased systolic blood pressure (SBP) (OR = 0.

NESFATIN-1 ACTIVITY IN THE BLOOD SERUM IN PATIENTS WITH CHRONIC HEART FAILURE OF ISCHEMIC ORIGIN AGAINST THE BACKGROUND OF TYPE 2 DIABETES MELLITUS AND OBESITY.

Objective: The aim: To study the nesfatin-1 activity in the blood serum of patients with chronic heart failure (CHF) of ischemic origin against the background of such metabolic disorders as type 2 diabetes mellitus (T2DM) and obesity.

Patients And Methods: Materials and methods: 154 patients with CHF were examined, and divided into 4 groups, according to the presence of metabolic disorders. Group 1 included patients with CHF on the background of coronary heart disease (CHD) and T2DM and obesity (n=42).

PROGNOSTICATION OF COMPLICATED COURSE OF ACUTE MYOCARDIAL INFARCTION WITH CONCOMITANT TYPE 2 DIABETES MELLITUS BASED ON USE OF ENDOTHELIAL MONOCYTE ACTIVATING POLYPEPTIDE-ІІ.

Objective: The aim: To determine the prognostic value of endothelial monocytic peptide ІІ in the course of AMI (acute myocardial infarction) in combination with type 2 diabetes mellitus (DM).

Patients And Methods: Materials and methods: The study involved 120 patients divided in 2 groups: Group 1 - patients with acute myocardial infarction (AMI) with concomitant type 2 DM (n=69); Group 2 - patients with AMI without concomitant type 2 DM (n=51). Control group was composed with 20 almost healthy persons.

THE DYNAMICS OF NEUROHUMORAL MEDIATORS OF VASOCONSTRICTION AND VASODILATION AND TROPONIN I IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION DEPENDING ON THE DEGREE OF CONCOMITANT OBESITY.

Objective: The aim: Is to evaluate copetin's, MRproADM's and troponin's I dynamic in patients with acute myocardial infarction depending on the degree of concomitant obesity.

Patients And Methods: Material and methods: The study included 105 patients with AMI. There were formed 2 groups: 1st group of patients with AMI and concomitant obesity (n=75), 2nd group - patients with AMI without obesity (n=30).

RELATIONSHIP BETWEEN INTERLEUKIN-6 GENE POLYMORPHISM AND HEART FAILURE IN PATIENTS WITH CORONARY ARTERY DISEASE AND OBESITY.

Objective: The aim: To examine the association between polymorphisms of the IL-6 gene promoter and HF in patients with CAD and obesity.

Patients And Methods: Material and methods: 222 patients with coronary artery disease and obesity were identified. Comparison group consisted of 115 patients with coronary artery disease with normal body weight.