Publications by authors named "N I Moiseeva"
An original method for the synthesis of a diverse array of hydroquinone thioethers with yields of 36% to 99% under mild conditions is described. The process is voltammetrically controlled and involves electrogenerating active protonated -quinone followed by thiol addition.
View Article and Find Full Text PDFIts broad spectrum of biological activity makes benzimidazole a fundamental pharmacophore in pharmaceutics. The paper describes newly synthesized AT-specific fluorescent bis-benzimidazole molecules DB2Py(n) that contain a pyrrolcarboxamide fragment of the antibiotic drug netropsin. Physico-chemical methods using absorption, fluorescence, and circular dichroism spectra have shown the ability of bis-benzimidazole- pyrroles to form complexes with DNA.
View Article and Find Full Text PDFOleanane aldehyde-β-enone (), being the semi-synthetic derivative of the triterpenoid betulin, effectively inhibits the proliferation of HBL-100 and K562 cancer cells (IC 0.47-0.53 µM), as well as the proliferation of their resistant subclones with high P-gp expression HBL-100/Dox, K562/i-S9 and K562/i-S9_Dox (IC 0.
View Article and Find Full Text PDFArticle Synopsis
- The study focused on creating co-delivery systems using paclitaxel and a prodrug of etoposide, utilizing human serum albumin (HSA) and poly(lactide-co-glycolide) nanoparticles.
- The nanoparticles were analyzed for various properties and demonstrated sizes of 90-150 nm, showing effective cytotoxicity against glioma cells, particularly Neuro2A cells.
- The results indicated a synergistic effect of the drug combinations, suggesting these delivery systems could enhance chemotherapy treatments for brain tumors, marking a novel approach using HSA-based formulations.
(1) Hypophosphatasia (HPP) is a rare inherited disease caused by mutations (pathogenic variants) in the ALPL gene which encodes tissue-nonspecific alkaline phosphatase (TNSALP). HPP is characterized by impaired bone mineral metabolism due to the low enzymatic activity of TNSALP. Knowledge about the structure of the gene and the features and functions of various ALPL gene variants, taking into account population specificity, gives an understanding of the hereditary nature of the disease, and contributes to the diagnosis, prevention, and treatment of the disease.
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