Early neutrophil gelatinase-associated lipocalin (NGAL) measurement could rule out future acute kidney injury in patients with acute coronary syndrome-Prospective observational study.

Background And Aims: The diagnosis of acute kidney injury (AKI) is of importance among patients with ST segment elevation (STEMI) undergoing primary coronary intervention (PCI). It is often delayed given the need in serial measurements of creatinine or other serum markers. Neutrophil gelatinase-associated lipocalin (NGAL) is a proven marker for AKI, although its role as an early predictor in this setting was scarcely addressed before and was the aim of our study.

Cognitive dysfunction in early experimental metabolic dysfunction-associated steatotic liver disease is associated with systemic inflammation and neuroinflammation.

Background & Aims: Cognitive dysfunction is an increasingly recognised manifestation of metabolic dysfunction-associated steatotic liver disease (MASLD), but the mechanistic link remains unclear. The aim of this study was to investigate the hypothesis that experimental MASLD leads to cognitive dysfunction via systemic inflammation and neuroinflammation.

Methods: Twenty male Sprague Dawley rats were randomised to a high-fat high-cholesterol (HFHC) diet to induce MASLD, or a standard diet (n = 10/group), for 16 weeks.

Proposed Musculoskeletal Examination of Youth and Adolescent Baseball Players.

With a wide range of injuries in youth baseball, and more than 12 million amateur baseball players in the United States, a comprehensive list of tests and measures may be helpful to assess strength, mobility, and motor control throughout the kinetic chain to reduce risk of injury in this population. Many studies have looked at youth baseball players using a single test or a small number of tests to determine the prevalence of specific injuries in youth baseball, but to this author's knowledge, there is no comprehensive musculoskeletal screen published at this time specific to youth baseball. The purpose of this article is to review literature published over the last year relative to injury in youth and adolescent baseball players in an effort to update the reader on current concepts, risk factors in this population, and to provide an updated systematic screening process that may be used in reducing injury rates.

Influence of Microgravity on Apoptosis in Cells, Tissues, and Other Systems In Vivo and In Vitro.

All life forms have evolved under the constant force of gravity on Earth and developed ways to counterbalance acceleration load. In space, shear forces, buoyance-driven convection, and hydrostatic pressure are nullified or strongly reduced. When subjected to microgravity in space, the equilibrium between cell architecture and the external force is disturbed, resulting in changes at the cellular and sub-cellular levels (e.