Histochemical and morphological changes in various regions of the rat hippocampus in swimming-induced stress.

Swimming stress increased the functional activity of hippocampal pyramidal neurons in rats, as indicated by decreases in their glycogen contents and increases in their nucleic acid contents and the nucleus:cytoplasm ratio. These changes were most marked in hippocampal field CA1, while changes in other regions of the hippocampus were minimal.

[Histochemical and morphometric evidence of the participation of dorsal hippocampal neurons in the antistress effect of melatonin].

The epiphyseal hormone melatonin (0.1 mg/kg) does not influence the functional state of pyramidal neurons in the dorsal hippocamp of intact rats, but decreases the swimming-stress-induced activation of these neurons. Removal of the pineal gland increased the functional activity of neurons in the intact rats and potentiated the stress-induced histochemical and morphometric changes.

[Swimming stress-induced histochemical and morphological changes in various regions of the rat hippocampus].

In rats, swimming stress enhanced functional activity of the hippocampus' pyramidal neurones as manifested by diminishing of the glycogen contents, increasing amount of nucleic acids, augmented nucleus/cytoplasm ratio.

[Effect of diazepam on the metabolic and morphometric parameters of neurons in the dorsal hippocampus in normal and stressed rats].

Diazepam (0.5 mg/kg) decreases the swimming-stress-induced activation of the pyramidal neurons in the dorsal hippocamp. This is manifested by a decrease in the stress-induced glycogen consumption, an increase in the RNA content, and (less pronounced) increased in the nucleocytoplasmic ratio.