[Myostatin - a modern understanding of the physiological role and significance in the development of age-associated diseases.].

Myostatin is a protein belonging to the myokine class, the family of transforming growth factors β (TGF-β). The review article, based on the analysis of literature data, shows the key role of myostatin in the development of senile sarcopenia and cachexia in various pathological conditions, such as cancer, chronic heart failure, chronic renal failure, COPD, etc. The article discusses the structure of myostatin, provides a detailed diagram of the synthesis and activation of myostatin, the ways of implementing the mechanism of action as a negative regulator of muscle growth and differentiation in these pathological conditions.

Serial measurements of cardiac biomarkers in patients after allogeneic hematopoietic stem cell transplantation.

Background: Previous therapy with anthracyclines (ANT) and conditioning regimen followed by hematopoietic stem cell transplantation (HSCT) represents a high risk for development of cardiotoxicity. The aim of this study was to assess subclinical myocardial damage after HSCT using echocardiography and cardiac biomarkers--high sensitive cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and to identify patients at risk of developing clinical cardiotoxicity.

Patients And Methods: Thirty-seven patients who were treated with allogeneic HSCT for hematologic diseases at median age of 28 years at time of HSCT were studied.

Organization of spontaneous rhythm of the small intestine in healthy individuals and patients with stomach and colorectal cancer.

The distribution of the main frequencies of spontaneous rhythm of the small intestine in the 12.0-8.0 cycle/min range (by the aboral frequency gradient) was studied by the electrogastroenterographic method in healthy individuals and patients with stomach and colorectal cancer before and after gastrectomy and total removal of the large intestine.

Spontaneous activity of the stomach and large intestine in healthy individuals and patients with tumors before and after gastrectomy and colectomy.

We studied the distribution of main frequencies of spontaneous activity (in the range of 2-4 cycles/min) of the stomach and large intestine in healthy individuals and patients with stomach and colon cancer before and after gastrectomy and resection or total colectomy. The rhythm was recorded noninvasively (from body surface) with Ag/AgCl electrodes connected to a 3-channel portable electrogastrograph. We determined general peculiarities of rhythm formation in the stomach and large intestine in healthy individuals on an empty stomach and after mixed feeding and evaluated changes in spontaneous activity in patients with stomach and colon cancer before and after gastrectomy, resection, or total colectomy.