Interaction of natural polyhydroxy-1,4-naphthoquinones with superoxide anion-radical.

The interaction of natural polyhydroxy-1,4-naphthoquinones (PHNQ) with superoxide anion-radical (O2) was studied by UV--visible spectrophotometry. 3-Acetyl-2,6,7-trihydroxynaphthazarin (spinochrome C), 2,3,7-trihydroxynaphthazarin (spinochrome D), 2,3,6, 7-tetrahydroxynaphthazarin (spinochrome E), 6-ethyl-2,3, 7-trihydroxynaphthazarin (echinochrome A), 6-ethyl-2,3, 7-trimethoxynaphthazarin (trimethoxyechinochrome A), and 2, 3-dihydroxy-6,7-dimethylnaphthazarin (A618) were tested. Xanthine and xanthine oxidase were used to generate **O2.

[Acidity and interaction with superoxide anion radical of echinochrome and its structural analogs].

Weak acid properties, autoxidation and interaction of natural polyhydroxy1,4-naphthoquinones (PHNQ) with superoxide anion-radical (O2-.) were studied by methods of potentiometric titration, polarography, and UV- and visible spectrophotometry. Sea urchin pigments 3-acetyl-2,6,7-trihydroxynaphthazarin (spinochrome C), 2,3,6,7-trihydroxynaphthazarin (spinochrome D), 2,3,6,7-trihydroxynaphthazarin (spinochrome E), 6-ethyl-2,3,7-trihydroxynaphthazarin (echinochrome A), synthetic 2,3-dihydroxy-6,7-dimethylnaphthazarin and 6-ethyl-2,3,7-trimethoxynaphthazarin (trimethoxyechinochrome A) were tested.

[Pharmacokinetics and clinical efficacy of histochrome in patients with acute myocardial infarction].

The effect of the antioxidant histochrom on the size of the myocardial infarction and activity of the cardioselective enzyme creatine phosphokinase was studied in 45 patients with acute myocardial infarction during thrombolytic therapy. Changes in blood plasma histochrom concentration were studied in 7 patients with myocardial infarction after a single intravenous infusion of 100 mg of the drug. The pharmacokinetic parameters of the drug are shown.

[Effects of laser therapy on lipids and antioxidants in blood of patients with bronchial asthma].

Laser therapy was assessed for effects on lipoperoxides and free radical catchers in blood lipids of patients with bronchial asthma (BA). When a group of 52 BA patients was compared to healthy donors by dienic conjugates, vitamin E and overall lipid-soluble antioxidants levels in the whole blood and plasma, these appeared higher in the asthmatics. Combination of laser therapy with conventional treatment returned these parameters close to normal.