Publications by authors named "N I Karpukhina"

This study investigated the effect of rosmarinic acid (RA) on the immediate microtensile bond strength (µTBS) of 1-step self-etch adhesive to artificial caries-affected dentine (CAD), with or without NaOCl treatment. Dentine surfaces of 60 premolars were subjected to pH-cycling for artificial caries induction. Samples were randomly categorized into: NaOClRA group treated with 6% NaOCl and RA, RA group treated with RA solution, NaOCl group treated with 6% NaOCl, and untreated control group.

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The aim of this study was to investigate the effects of TiO/CaO addition on the crystallization and flexural strength of leucite glass-ceramics (GC). Synthesis of translucent and high strength GCs is important for the development of aesthetic and durable dental restorations. To achieve this, experimental aluminosilicate glasses (1-3 mol% TiO and CaO (B1, B2, B3)) were melted in a furnace to produce glasses.

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Article Synopsis
  • - The study aimed to evaluate how well triamcinolone acetonide (TA) permeates through a synthetic buccal membrane using different bilayer mucoadhesive film compositions.
  • - Tests were conducted using various film formulations (F1, F2, F3) containing different combinations of hydroxypropyl methylcellulose and polyvinylpyrrolidone, revealing that F1 had the highest drug retention and permeability.
  • - The research concluded that these mucoadhesive films, especially F1, could be effective for topical treatments of oral mucosal conditions like recurrent aphthous stomatitis.
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Introduction: Silver Diammine Fluoride (SDF) is a clinically used topical agent to arrest dental caries. However, the kinetics of its chemical interactions with hydroxyapatite (HA), the principal inorganic component of dental enamel, are not known. The aim was to characterize the step-wise chemical interactions between SDF and HA powder during the clinically important process of remineralization.

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Objectives: Recurrent aphthous stomatitis (RAS) is a painful disorder that commonly appears as ulcers on the oral mucosa, lasting ∼two weeks (minor) to months (major and herpetiform). Current treatment often necessitates the use of topical steroids in the form of pastes, mouthwashes, or gels, but these forms are often ineffective due to inadequate drug contact time with the ulcers. In this study, the performance of novel bilayer mucoadhesive buccal films loaded with triamcinolone acetonide (TA) has been evaluated for targeted drug delivery.

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