[Effect of chronic stress during pregnancy on the functional state of the hypothalamo-hypophyseo-adrenal system in the progeny].

A study was made of the effect of a chronic stress on the activity of the hypothalamo-hypophyseo-adrenal system in pregnant rats as well as on the development of its function in the progeny in postnatal ontogenesis. Experiments were made on pregnant Wistar rats and their progeny. A chronic stress in the 2nd half of pregnancy has been shown to have a detrimental effect on function of the hypothalamo-hypophyseo-adrenal system not only of pregnant animals but also of their progeny, particularly in early periods of postnatal development.