[Surgical treatment of inveterate defects of the hand II-V fingers extensors tendons in VI-VII zone].

Possibilities and efficacy of secondarily restoration of inveterate defects of the extensors tendons of fingers, owing various extent, were studied in conditions of cicatricial changes in the hand back skin. There was established, that in ischemic and reperfusion damage of the hand tissues the coarse cicatricial changes in the end portions of the traumatized tendons occurs, essentially influencing surgical tactics. Optimal operative techniques, directed on the extensors tendons restoration in various extent of their defects and various severity of the soft tissues changes in the hand back were determined.

[Transplantation of the muscular perforant flaps for restoration of tissues defects in the extremities].

There was summarized the experience of surgical treatment of 9 patients with the soft tissues defects of various etiology, localization and size, in whom microsurgical autotransplantation of the perforant flaps was performed on thoracospinal and medial gastrocnemial arteries. Peculiarities of preparation and mobilization of perforating vessels, securing the motor nerves branches, were presented. The perforant flaps advantages are: their small thickness, plasticity, mobility and minimal complications in the donor's zone.

[Experimental studying of the possible pharmacological defense of muscular flap tissues from ischemic and reperfusion injury during its free transplantation].

In experiment on muscle flaps of 20 rabbits the peculiarities of their tissues damage in the ischemia period, and also due to the oxygen-dependent processes activation (peroxidal and free radical oxidation of a membrane phospholipids) in period of its reperfusion were studied. Preliminary introduction of a lipin, unitiol and ascorbic acid mixture in the flap arterial channel had promoted the reduction of damage severity in the translocated flap cells biomembranes due to ischemia and reperfusion, causing inhibition of the lipids peroxidal oxidation processes, rising of the flap tissues antioxidant defense, the cell and subcell membranes stabilization which preserves the vessels endothelium integrity. This showed a promising future for application of these preparations in a free transplantation of compound tissue complexes.