E-jet 3D printed aligned nerve guidance conduits incorporated with decellularized extracellular matrix hydrogel encapsulating extracellular vesicles for peripheral nerve repair.

Peripheral nerve injury (PNI) as a common clinical issue that presents significant challenges for repair. Factors such as donor site morbidity from autologous transplantation, slow recovery of long-distance nerve damage, and deficiencies in local cytokines and extracellular matrix contribute to the complexity of effective PNI treatment. It is extremely urgent to develop functional nerve guidance conduits (NGCs) as substitutes for nerve autografts.

The 10-Year Outcomes of Single- versus Double-Bundle Anterior Cruciate Ligament Reconstruction: A Systematic Review.

Single-bundle (SB) and double-bundle (DB) anterior cruciate ligament reconstruction (ACLR) have been compared for years, and long-term outcomes of the two techniques remain inconclusive. We compared the 10-year outcomes of SB and DB reconstruction, in terms of subjective scores, knee stability, graft failure, and osteoarthritis (OA). We searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials for relevant studies, without restrictions on study design, language, or publication date.

An Electroglottographic and Acoustic Study on Mandarin Speech in Male Heroin Users.

Drug abuse can cause severe damage to the human speech organs. The vocal folds are one of the important speech organs that produce voice through vibration when airflow passes through. Previous studies have reported the negative effects of drugs on speech organs, including the vocal folds, but there is still limited research on relevant field.

Boosting Rice Resilience: Role of Biogenic Nanosilica in Reducing Arsenic Toxicity and Defending against Herbivore.

The use of nanoparticles is a promising ecofriendly strategy for mitigating both abiotic and biotic stresses. However, the physiological and defense response mechanisms of plants exposed to multiple stresses remain largely unexplored. Herein, we examined how foliar application of biogenic nanosilica (BNS) impacts rice plant growth, molecular defenses, and metabolic responses when subjected to arsenic (As) toxicity and infested by the insect .

Progress of cGAS-STING signaling pathway-based modulation of immune response by traditional Chinese medicine in clinical diseases.

The cGAS-STING signaling pathway is a critical component of the innate immune response, playing a significant role in various diseases. As a central element of this pathway, STING responds to both endogenous and exogenous DNA stimuli, triggering the production of interferons and pro-inflammatory cytokines to enhance immune defenses against tumors and pathogens. However, dysregulated activation of the STING pathway is implicated in the pathogenesis of multiple diseases, including autoinflammation, viral infections, and cancer.