Publications by authors named "N I Bodrug"
Article Synopsis
- Vascular patterning is important for growth and development, and the ERG factor helps control blood vessel formation.
- Scientists found that certain changes in a specific protein called FAK can affect how much ERG and another protein called DLL4 are made, which leads to problems in blood vessel formation.
- They discovered that FAK interacts with two other proteins, USP9x and TRIM25, which helps manage ERG levels and can fix issues with blood vessels when ERG is restored.
Background And Aim: Atrophic gastritis is a precancerous gastric lesion, therefore its early detection is a priority in preventing gastric cancer. The aim of the present paper is to develop a narrative synthesis of the present knowledge on diagnostic methods of chronic atrophic gastritis.
Methods: A literature search was carried out on main databases: PubMed, Hinari, SpringerLink and Scopus (Elsevier) for the period 2000-2020.
Enhanced blood vessel (BV) formation is thought to drive tumor growth through elevated nutrient delivery. However, this observation has overlooked potential roles for mural cells in directly affecting tumor growth independent of BV function. Here we provide clinical data correlating high percentages of mural-β3-integrin-negative tumor BVs with increased tumor sizes but no effect on BV numbers.
View Article and Find Full Text PDFExpression of focal adhesion kinase (FAK) in endothelial cells (EC) is essential for angiogenesis, but how FAK phosphorylation at tyrosine-(Y)397 and Y861 regulate tumor angiogenesis is unknown. Here, we show that tumor growth and angiogenesis are constitutively reduced in inducible, ECCre+; -mutant mice. Conversely, ECCre+; mice exhibit normal tumor growth with an initial reduction in angiogenesis that recovered in end-stage tumors.
View Article and Find Full Text PDFObjectives: Chemokines play a key role in immune regulation and response, and have been implicated in the pathogenesis of tuberculosis (TB). In this study, we investigated whether functional polymorphisms of the chemokines CCL5, CCL2, and CXCL8 are associated with pulmonary TB in a Moldavian population.
Materials And Methods: A total of 250 patients with TB and 184 healthy controls were screened for CCL5 -403G/A (rs2107538), CCL5 In1.