[Effects of dalargin on proliferative processes and vertical migration of cells of the corneal epithelium during stress].

We studied the effect of synthetic analogue of opioid peptides dalargin on kinetics of cell population of corneal epithelium during stress. It was found out that dalargin introduction before stress decreased the level of pathological mitoses induced by the acute stress action in white rats early in the morning. Dalargin prevented the activation of the proliferative process after the repeated stress activation, made stress milder.

[Acceleration of the vertical migration of corneal epithelial cells in white rats under chronic immobilization stress].

Autoradiography with 3H-thymidine was employed to study DNA synthesis and the rate of the migration of labeled nuclei from the basal layer to the surface layers of albino rat corneal epithelium after repeated immobilization stress. The studies were performed at once, and 24 and 72 hours after 3H-thymidine injection. Post-stressor activation of DNA synthesis and acceleration of the vertical migration of the cells were recorded.