[Mechanisms of anti-inflammatory activity of antioxidants in lung tuberculosis].

The experiment on 120 non-inbred albino rats with induced pulmonary destructive tuberculosis has established that the antiinflammatory action of the antioxidant dibunol is displayed through changes in the ratio of biologically active 11-hydroxycorticosteroids--free hydrocortisone and corticosterone.

[Endobronchial laser therapy of post-tuberculosis bronchial fibrous stenosis].

The results of endobronchial treatment of 9 patients with post-tuberculous fibrous stenoses of large bronchi by using neodymium-YAG laser are presented. After recanalization of fibrous stenoses the patients were given antioxidants (7.5% sodium thiosulfate solution, 0.

[Dynamics of biochemical indices in a favorable course of sarcoidosis of the respiratory organs].

Sarcoidosis ran a favourable course in 166 out of 179 patients. The active phase of sarcoidosis was characterized by dysproteinemia, high content of histamine, STH and beta-lipoproteins together with a decrease of HPI and total protein. More remarkable shifts were observed in patients afflicted with sarcoidosis of the intrathoracic lymph nodes and of the lungs.

[The pro-fibrotic and pro-oxidant action of isoniazid].

As a result of experimental research on rats with destructive pulmonary tuberculosis, oxidative action of isoniazid in a dose of 50 mg per kg body weight, corresponding to the mean therapeutic dose of 10 mg/kg in man, was clearly defined. Fibrotic action of the drug was also shown. It manifested itself by a sharp rise of insoluble collagen levels in the lung tissue tuberculous lesion focus of the treated animals and in the formation of mature connective tissue.