Publications by authors named "N Hueffmeyer"

Introduction: Diffuse intrinsic pontine gliomas are associated with dismal survival outcomes. Conventional fractionation radiation to a dose of 60 Gy is the standard of treatment. This retrospective review aims to compare survival and toxicity outcomes of patients treated with conventional fractionation (CF) and hypofractionation (HF) radiotherapy.

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Peroxiredoxin 6 (Prdx6), a unique non-seleno peroxidase, is a bifunctional protein with GSH peroxidase at pH 7.4 and calcium independent phospholipase A (aiPLA ) activities at pH 4.0.

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Purpose: Acrylic dentures fabricated using polymethyl methacrylate are subjected to either intraoral fatigue stress or extraoral impact stress, eventually forming microcracks and fractures. This limitation should be overcome by either modification in the acrylic resin material or in polymerization techniques. This study compares the impact strength and flexural strength of high-impact resin to conventional resin in short- and long-heat polymerization settings.

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Introduction: Leprosy is a common infectious disease in India that can lead to nerve damage and disability. There is a dearth of knowledge regarding leprosy not only among the general public but also among healthcare workers. This knowledge gap leads to the generation of stigma and delay in the detection of new cases.

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Article Synopsis
  • RbgA is a GTPase that plays a crucial role in the maturation of the 50S ribosomal subunit, favoring its GTP-bound state over the GDP-bound state due to conformational differences.
  • All-atom molecular dynamics simulations revealed significant conformational changes in RbgA depending on the bound nucleotide, particularly under GTP-Mg and GMPPNP-Mg conditions, which may impact its function.
  • The study identifies key regions that influence RbgA's ribosome association and suggests that understanding these mechanisms can help develop new chemical agents to regulate ribosome biogenesis.
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