Publications by authors named "N Hubner"
Psychological measures frequently show trait-like properties, and the ontological status of stable psychological traits has been discussed for decades. We argue that these properties can emerge from causal dynamics of time-varying processes, which are from the analysis model, potentially leading to the estimation of traits that are, at least in part, illusory. Theories positing the importance of a large set of dynamic psychological causes across development are consistent with the existence of illusory traits.
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- Interleukin 11 (IL11) was initially developed as a treatment for low platelet levels but has shown serious cardiac side effects, prompting researchers to investigate its toxic effects on heart cells for the first time.
- The study involved injecting recombinant IL11 into mice and using various scientific techniques to assess its effects on heart function and gene expression, revealing drastic reductions in heart performance and increased activation of inflammatory pathways.
- Findings from cardiomyocyte-specific knockout mouse models showed that IL11 directly induces stress responses and gene expression changes in heart cells, further solidifying its role in heart toxicity rather than protection.
Prostate biopsies are commonly performed for the early detection of prostate cancer and yet are associated with risks of life-threatening infections. Drug-resistant strains of Escherichia coli are the most common etiologic agents. Multiple maneuvers can reduce the risk of postbiopsy infections and sepsis during transrectal prostate biopsy including periprocedural empiric or targeted prophylactic antibiotics (based on previous rectal culture) and prebiopsy rectal cleansing with a povidone-iodine solution.
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- Evolutionary changes in RNA translation rates and new genes, including small open reading frames, play a key role in the development of innovations in primates and rodents.
- This study examined the hearts of four primate species and two rodent species using advanced ribosome and transcriptomic profiling techniques, focusing on adult heart tissues and stem cell-derived heart cells.
- Findings revealed rapid evolution in the translation efficiency of mitochondrial complexes and identified numerous unique genomic features related to primate heart evolution, highlighting mechanisms that influence cardiac development and potential disease.