Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia.

Schizophrenia (SZ) is a deleterious brain disorder characterised by its heterogeneity and complex symptomatology consisting of positive, negative and cognitive deficits. Current antipsychotic drugs ameliorate the positive symptomatology, but are inefficient in treating the negative symptomatology and cognitive deficits. The neurodevelopmental glutamate hypothesis of SZ has opened new avenues in the development of drugs targeting the glutamatergic system.

Monkey Lateral Prefrontal Cortex Subregions Differentiate between Perceptual Exposure to Visual Stimuli.

Each day, humans must parse visual stimuli with varying amounts of perceptual experience, ranging from incredibly familiar to entirely new. Even when choosing a novel to buy at a bookstore, one sees covers they have repeatedly experienced intermixed with recently released titles. Visual exposure to stimuli has distinct neural correlates in the lateral prefrontal cortex (LPFC) of nonhuman primates.

Analysis of the Monophyletic Lineage of Avian Influenza H5N1 Which Circulated in Venezuelan Birds During the 2022-2023 Outbreak.

Avian influenza subtype H5N1 has caused outbreaks worldwide since 1996, with the emergence of the Guandong lineage in China. The current clade 2.3.

Future Trends in Alternative Sustainable Materials for Low-Temperature Thermoelectric Applications.

In the evolution of pervasive electronics, it is imperative to significantly reduce the energy consumption of power systems and embrace sustainable materials and fabrication processes with minimal carbon footprint. Within this context, thermoelectric generators (TEGs) have garnered substantial attention in recent years because of the readily available thermal gradients in the environment, making them a promising energy-harvesting technology. Current commercial room-temperature thermoelectrics are based on scarce, expensive, and/or toxic V-VI chalcogenide materials, which limit their widespread use.