Publications by authors named "N Horiuchi"
Understanding metabolic conditions related to glycolysis dependence is crucial for developing new treatments in cancer and regenerative medicine. This protocol details a method for using the live-cell metabolic analyzer (LiCellMo) to measure continuous changes in glucose consumption and lactate production in cultured human cells. LiCellMo provides real-time data on consecutive metabolic changes, improving measurements of these processes in various contexts, including in cancer and regenerative treatments.
View Article and Find Full Text PDFWhether or not vascular endothelial growth factor pathway inhibitors (VPIs) increase the risk of artery dissection is still unknown. This study aimed to quantitatively evaluate the possibility of artery dissection as a class effect of VPIs using nationwide real-world data. This cohort study was conducted based on the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB), which spans nearly the entire Japanese population of over 100 million individuals.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted in Japan to assess the risk of neutropenia (low neutrophil count) in psoriasis patients treated with anti-IL-23 antibodies compared to other treatments.
- Researchers analyzed data from 1,309 patients who were prescribed various biologic treatments between 2009 and 2021.
- The findings indicated that anti-IL-23 antibodies did not show a significant increase in neutropenia risk compared to anti-IL-17 antibodies, adalimumab, or apremilast.
Background: In the post-marketing stage, cases of hypocalcemia associated with bisphosphonate preparations (BPs) have been reported in patients with decreased kidney function, despite warning against use of BPs in such patients in the package insert (PI) of Japan. The purpose of this study was to investigate the safety of BPs in patients with decreased kidney function.
Methods: The cohort study was conducted in patients with osteoporosis and newly prescribed bisphosphonate utilizing real-world data from MID-NET in Japan.