Publications by authors named "N Horikawa"

Background: In 2018, the International Federation of Gynecology and Obstetrics (FIGO) revised its cervical cancer staging system to enhance clinical relevance, notably by categorizing lymph node metastases (LNM) as an independent stage IIIC. This multicenter study evaluates the prognostic implications of the FIGO 2018 classification within a Japanese cohort.

Methods: This study included 1468 patients with cervical cancer.

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Introduction: Uterine carcinosarcoma (UCS) and uterine sarcomas (US) are rare but aggressive cancer with poor prognoses. The prognostic value of systemic inflammatory response (SIR) indicators, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), in predicting outcomes of UCS and US remains unclear. This study investigated the prognostic significance of SIR indicators for UCS and US.

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Article Synopsis
  • A 71-year-old man with metastatic hormone-sensitive prostate cancer was treated with a combination of medications and palliative radiation therapy targeting specific bones.
  • Following the treatment, he developed severe neutropenia on day 35, which halted his treatment and led to a recovery period of 23 days using a granulocyte colony-stimulating factor.
  • The case highlights the critical need to prioritize treatment by focusing on specific lesions and to avoid irradiating areas rich in red bone marrow to prevent severe hematological toxicity.
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  • * Intraoperative elastography was used during surgery to ensure complete removal of the adenomyotic tissue while protecting the endometrium, with MRI confirming no remaining adenomyosis post-surgery.
  • * The patient achieved a successful twin delivery via cesarean section after IVF, signaling the potential of elastography-guided surgery for enhancing fertility in women with adenomyosis, though more research is needed to confirm its effectiveness and safety.
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Zinc (Zn) is an essential element for plants. Numerous proteins in different cellular compartments require Zn for their structure and function. Zn can be toxic when it accumulates in high levels in the cytoplasm.

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