Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection.

Urinary tract infections (UTIs) commonly afflict people with diabetes. To better understand the mechanisms that predispose diabetics to UTIs, we employ diabetic mouse models and altered insulin signaling to show that insulin receptor (IR) shapes UTI defenses. Our findings are validated in human biosamples.

Impulsive noise pollution in the Northeast Atlantic: Reported activity during 2015-2017.

Underwater noise pollution from impulsive sources (e.g. explosions, seismic airguns, percussive pile driving) can affect marine fauna through mortality, physical injury, auditory damage, physiological stress, acoustic masking, and behavioural responses.

Optimising clinical effectiveness and quality along the atrial fibrillation anticoagulation pathway: an economic analysis.

Background: Atrial fibrillation (AF) represents the most common sustained cardiac arrhythmia. A service evaluation was carried out at an anticoagulation clinic in Newcastle upon-Tyne to explore the efficacy of introducing self-testing of anticoagulation status for AF patients on warfarin. The analysis presented aims to assess the potential cost savings and clinical outcomes associated with introducing self-testing at a clinic in the Northeast of England, and to determine the cost-effectiveness of a redesigned treatment pathway including genetic testing and self-testing components.

The development and evaluation of a brief risk screening instrument for the psychiatric inpatient setting.

This paper reports on the development and evaluation of a risk screening instrument (RSI) intended for use by nursing staff on general acute psychiatric admission wards. The RSI comprised six questions concerning patient status on admission (e.g.