Publications by authors named "N Hirota"
Brexpiprazole treatment for agitation in Alzheimer's dementia: A randomized study.
Alzheimers Dement
November 2024
Introduction: We evaluated the efficacy and safety of brexpiprazole for the treatment of agitation in Alzheimer's dementia (AAD) in Japanese patients.
Methods: This was a phase 2/3 multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Patients with AAD were randomized to receive brexpiprazole 1 mg/day or 2 mg/day, or placebo (3:4:4) for 10 weeks.
Pericardial effusion (PE) presentation varies from an incidental finding to a life-threatening situation; thus, its etiology and clinical course remain unknown. The aim of the present study was to retrospectively investigate these factors.We analyzed 171 patients (0.
View Article and Find Full Text PDFValidity and Reproducibility of a Food Frequency Questionnaire for Dietary Assessment in Japanese People.
J Nutr Sci Vitaminol (Tokyo)
April 2024
A 76-item food frequency questionnaire (FFQ) was developed to investigate nutritional epidemiology in urban residents in Japan. The authors prepared two food models-a life-size three-dimensional model and a life-size two-dimensional photograph-to assess the FFQ portion size. The validity of the FFQ was verified using the two food models by comparing them with 16-d weighted dietary records (WDRs).
View Article and Find Full Text PDFArticle Synopsis
- A study examined the effectiveness of convolutional neural networks (CNNs) integrated with electrocardiograms (ECGs) for identifying hypertrophic cardiomyopathy (HCM) and dilated HCM (dHCM) in a large patient dataset (19,170 total, with 140 HCM/dHCM cases).
- The analysis focused on two diagnostic models—one for overall disease detection and another that considered different disease subtypes—showing that while overall sensitivity started at 76%, it reached 100% when specific conditions were met (diagnostic probability ≥ 0.9 and left ventricular hypertrophy present).
- The research concluded that while initial detection rates of HCM or dHCM using CNNs in
Article Synopsis
- * The CNN model achieved a high area under the curve (AUC) score of 0.936 for AD detection with eight-lead ECGs but had a low overall positive predictive rate (PPR) of 7%. However, the PPR improved significantly to 35% for patients with high D-dimer levels and a history of hypertension.
- * The single-lead V1 ECG also demonstrated strong performance, with an A