Publications by authors named "N Hayward"
Article Synopsis
- - Genetic analysis of 88 uveal melanoma patients found that 6 carried germline BAP1 variants, but no significant difference in oncogenic mutations was observed between those carriers and sporadic cases.
- - Patients with somatic BAP1 mutations (24 individuals) had a notably poorer prognosis compared to those without mutations, while germline carriers showed no significant difference in overall survival.
- - Notably, all stage III patients with somatic BAP1 mutations (7 patients) experienced metastasis, whereas some early-stage tumors (4 of 28) with somatic mutations remained metastasis-free for over five years.
Article Synopsis
- Our environment and experiences shape our behavior and mental states, but we lack understanding of how brain connectivity responds to these changes over time.
- A study collected 133 days of data from one subject using smartphones and fMRI scans, revealing that past behavior can influence brain connectivity for up to 15 days.
- The research emphasizes the need to consider the interaction between brain connectivity and external factors, supporting more precise healthcare and advancing the field of environmental neuroscience.
Germline Variants in Patients Affected by Both Uveal and Cutaneous Melanoma.
Pigment Cell Melanoma Res
January 2025
Uveal melanoma (UM) and nonacral cutaneous melanoma (CM) are distinct entities with varied genetic landscapes despite both arising from melanocytes. There are, however, similarities in that they most frequently affect people of European ancestry, and high penetrance germline variants in BAP1, POT1 and CDKN2A have been shown to predispose to both UM and CM. This study aims to further explore germline variants in patients affected by both UM and CM, shedding light on the underlying genetic mechanism causing these diseases.
View Article and Find Full Text PDFImportance: It is unknown whether germline genetic factors influence in situ melanoma risk differently than invasive melanoma risk.
Objective: To determine whether differences in risk of in situ melanoma and invasive melanoma are heritable.
Design, Setting, And Participants: Three genome-wide association study meta-analyses were conducted of in situ melanoma vs controls, invasive melanoma vs controls, and in situ vs invasive melanoma (case-case) using 4 population-based genetic cohorts: the UK Biobank, the FinnGen cohort, the QSkin Sun and Health Study, and the Queensland Study of Melanoma: Environmental and Genetic Associations (Q-MEGA).
Persimmon fruit processing-derived waste and by-products, such as peels and pomace, are important sources of dietary fiber and phytochemicals. Revalorizing these by-products could help promote circular nutrition and agricultural sustainability while tackling dietary deficiencies and chronic diseases. In this study, fiber-rich fractions were prepared from the by-products of Sharoni and Brilliant Red persimmon varieties.
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