Shorter vs. standard-duration antibiotic therapy for nocardiosis: a multi-center retrospective cohort study.

Purpose: The prolonged treatment recommended for nocardiosis does not rely on strong evidence. Consequently, some clinicians opt shorter therapy in certain circumstances. We assessed the effectiveness of shorter therapy.

GP100 expression is variable in intensity in melanoma.

Drugs or cellular products that bind to gp100 are being investigated for treatment of cutaneous melanoma. The relative specificity of gp100 expression in melanocytes makes it an attractive target to harness for therapeutic intent. For example, Tebentafusp, a bispecific gp100 peptide-HLA-directed CD3 T cell engager, has generated significant enthusiasm in recent years due to its success in improving outcomes for uveal melanoma and is being studied in cutaneous melanoma.

Upland Yedoma taliks are an unpredicted source of atmospheric methane.

Landscape drying associated with permafrost thaw is expected to enhance microbial methane oxidation in arctic soils. Here we show that ice-rich, Yedoma permafrost deposits, comprising a disproportionately large fraction of pan-arctic soil carbon, present an alternate trajectory. Field and laboratory observations indicate that talik (perennially thawed soils in permafrost) development in unsaturated Yedoma uplands leads to unexpectedly large methane emissions (35-78 mg m d summer, 150-180 mg m d winter).

Early Identification of Children at Risk of Communication Disorders: Introducing a Novel Battery of Dynamic Assessments for Infants.

Purpose: Many children with communication disorders (CDs) experience lengthy gaps between parental reporting of concerns and formal identification by professionals. This means that children with CDs are denied access to early interventions that may help support the development of communication skills and prevent possible negative sequelae associated with long-term outcomes. This may be due, in part, to the lack of assessment instruments available for children younger than 3 years of age.

Distribution of water phase near the poles of the Moon from gravity aspects.

Our Moon periodically moves through the magnetic tail of the Earth that contains terrestrial ions of hydrogen and oxygen. A possible density contrast might have been discovered that could be consistent with the presence of water phase of potential terrestrial origin. Using novel gravity aspects (descriptors) derived from harmonic potential coefficients of gravity field of the Moon, we discovered gravity strike angle anomalies that point to water phase locations in the polar regions of the Moon.