Exploring Pre-trained General-purpose Audio Representations for Heart Murmur Detection.

To reduce the need for skilled clinicians in heart sound interpretation, recent studies on automating cardiac auscultation have explored deep learning approaches. However, despite the demands for large data for deep learning, the size of the heart sound datasets is limited, and no pre-trained model is available. On the contrary, many pre-trained models for general audio tasks are available as general-purpose audio representations.

Theaflavin 3'-gallate activates G protein-coupled receptor 55 (GPR55) and enhances GLP-1 secretion Ca/CaMKII/ERK signaling in enteroendocrine STC-1 cells, mitigating postprandial hyperglycemia in mice.

The antihyperglycemic effect of black tea is well-known, and theaflavins (TFs) are considered active compounds. It is, however, unclear whether glucagon-like peptide-1 (GLP-1) is involved in the antihyperglycemic effects of TFs. We demonstrate that TFs suppress postprandial hyperglycemia by stimulating GLP-1 secretion in mice.

Telehealth and virtual supervision practices for health professions education in the Department of Veterans Affairs.

Background: Telehealth and virtual supervision practices in health professions clinical education has grown rapidly, including in the Department of Veterans Affairs (VA) which oversees the largest interprofessional training effort in the United States. Telehealth is the provision of healthcare that is provided remotely through telecommunication technology, and virtual supervision is clinical supervision of health professions trainees (HPTs) that occurs through telecommunication technology. In this study we evaluate participation in telehealth and virtual supervision for physician, nursing, and associated health HPTs, and describe prevalent themes concerning HPT perceptions of telehealth and virtual supervision.

Elevated mepolizumab levels in patients with severe asthma responsive to 1 year's mepolizumab treatment.

Background: Asthma involves variable airflow limitation and persistent airway inflammation. Eosinophilic asthma, characterized by cytokine-mediated type 2 inflammation, is generally treated with inhaled corticosteroids. However, patients with severe asthma may require biologics, such as mepolizumab, which targets IL-5 and can manage uncontrolled eosinophilic asthma.