Publications by authors named "N Hakime"
Objective: Describe susceptibility and molecular profiles among Enterobacteriaceae pathogens and to explore if war, among other factors, can affect antimicrobial resistance.
Methods: Clinical isolates from the Study for Monitoring Antimicrobial Resistance Trends associated with urinary tract and intra-abdominal infections between 2011 and 2015 were identified in Lebanon and Jordan. Susceptibility testing and molecular characterization were performed as per standard methods.
Assessment of Molecular Markers in AML Patients: A Hospital-Based Study in Lebanon.
Clin Lymphoma Myeloma Leuk
June 2015
Article Synopsis
- This study aimed to explore the genetic characteristics of acute myelogenous leukemia (AML) in Lebanese patients, focusing on specific genetic rearrangements and mutations.
- Researchers analyzed 144 bone marrow samples and found recurrent genetic abnormalities such as t(15;17) in a significant number of patients, while 35.5% of cases showed a normal karyotype.
- The findings align with international research, indicating that around 35% of AML patients may have cytogenetically normal results, which suggests the need for further testing to identify potential mutations in these cases.
Objectives: The acquisition of carbapenemases by Acinetobacter baumannii is reported increasingly worldwide, but data from Lebanon are limited. The aims of this study were to evaluate the prevalence of imipenem-resistant A. baumannii in Lebanon, identify resistance determinants, and detect clonal relatedness.
View Article and Find Full Text PDFMyelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by peripheral blood cytopenias, blood cells dysplasia, and increased risk for progression to acute leukemia.Physicians should be vigilant in diagnosing MDS and should be aware of the contemporary therapies that are always in progress. Most of the data on MDS epidemiology and management comes from developed countries.
View Article and Find Full Text PDFObjectives: To detect, characterize, and assess the genetic clonality of carbapenem-non-susceptible Enterobacteriaceae in 10 Lebanese hospitals in 2012.
Methods: Selected Enterobacteriaceae isolates with reduced susceptibility to carbapenems were subject to phenotypic study including antibiotic susceptibility, cloxacillin effect, modified Hodge test, and activity of efflux pump inhibitor. Carbapenemase genes were detected using PCR; clonal relatedness was studied by pulsed field gel electrophoresis.