Publications by authors named "N Hakan Temiz"
Background: Malignant peripheral nerve sheath tumors (MPNSTs) can arise from atypical neurofibromas (ANF). Loss of the polycomb repressor complex 2 (PRC2) is a common event. Previous studies on PRC2-regulated genes in MPNST used genetic add-back experiments in highly aneuploid MPNST cell lines which may miss PRC2-regulated genes in -mutant ANF-like precursor cells.
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- Higher brain functions rely on how experiences shape information representation, potentially organized through attractor dynamics or changes in neural manifolds.
- Research on zebrafish's olfactory responses showed that instead of attractor dynamics, training improved the differentiation of neural representations for relevant odors, in line with autoassociative network models.
- The geometry of these neural manifolds was crucial for classifying sensory information and predicting odor discrimination, indicating that areas like pDp might encode information in a way that supports both sensory and meaningful learning.
Perception can be refined by experience, up to certain limits. It is unclear whether perceptual limits are absolute or could be partially overcome via enhanced neuromodulation and/or plasticity. Recent studies suggest that peripheral nerve stimulation, specifically vagus nerve stimulation (VNS), can alter neural activity and augment experience-dependent plasticity, although little is known about central mechanisms recruited by VNS.
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- - Tobacco use is linked to various cancers and causes about 25% of cancer-related deaths, primarily due to harmful substances in tobacco smoke, including tobacco-specific nitrosamines like NNN and NNK that create damaging DNA adducts.
- - The study identified new mutational patterns induced by these DNA adducts, particularly in certain cancer cell lines and rat tumors, indicating specific mutations that occur in the DNA from exposure to these harmful compounds.
- - Analyzing 2,780 cancer genomes revealed that these mutational patterns were present in around 180 tumors from types of cancer not typically associated with smoking, suggesting that the damage caused by the POB pathway could play a unique role in various cancers, including hematological
Antiviral DNA cytosine deaminases APOBEC3A and APOBEC3B are major sources of mutations in cancer by catalyzing cytosine-to-uracil deamination. APOBEC3A preferentially targets single-stranded DNAs, with a noted affinity for DNA regions that adopt stem-loop secondary structures. However, the detailed substrate preferences of APOBEC3A and APOBEC3B have not been fully established, and the specific influence of the DNA sequence on APOBEC3A and APOBEC3B deaminase activity remains to be investigated.
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